Phase 2 Endometrial Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People aged between 18 and 70 years
• People who have been diagnosed with cervical cancer (confirmed by a tissue or cell sample) at a specific stage of disease — FIGO stage IB3 or IIA2
• People whose scans show that the lymph nodes in the pelvis and near the main abdominal artery are below a certain size (less than 1.5 cm in a specific measurement)
• People whose cervical cancer has been identified as one of three specific types: squamous cell carcinoma, adenocarcinoma, or adenosquamous carcinoma
• People who have not previously received any cancer treatment
• People who are generally well enough to carry out daily activities, meeting a standard health and activity measure known as ECOG performance status 0 or 1 (confirm with trial site)

Who may not be able to join:

• People who have another type of cancer at the same time
• People who are pregnant or have recently given birth
• People with a history of heart attack, stroke, unstable chest pain, severe heart failure, or blood clots in a deep vein
• People with certain heart rhythm problems of a moderate or serious level, including any degree of atrial fibrillation, or other significant rhythm problems that require treatment (confirm with trial site)
• People with active, unresolved hepatitis — meaning ongoing symptoms such as loss of appetite, weakness, nausea, or jaundice — or, for hepatitis B specifically, a virus level above a certain threshold in blood tests
• People whose liver is not functioning well enough, based on specific blood test results being more than 2.5 times the normal upper limit
• People whose kidneys are not functioning well enough, based on a specific blood test result being more than twice the normal upper limit
• People with a history of long-term lung disease that limits breathing capacity
• People who have had a major organ transplant or have an autoimmune disease
• People with a history of severe mental illness or significant brain-related conditions affecting function
• People with a history of substance abuse or drug addiction
• People who have been taking immune-suppressing medications or steroid medicines (above a certain dose) within the two weeks before joining, and are still taking them
• People with blood clotting problems, a tendency to bleed, or who are currently on blood-thinning or clot-dissolving therapy (note: low-dose aspirin and a specific type of low-dose heparin are generally permitted — confirm with trial site)
• People with an immune system deficiency, whether present from birth or developed — for example, those with HIV infection
• People who have received an inactivated (non-live) vaccine within 30 days before the first study treatment
• People who are unable or unwilling to give written consent to participate, or who are unable to follow the requirements of the study

Important: Always verify eligibility with the trial site directly before applying.