Phase 1 Kidney Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are between 18 and 70 years old (inclusive), regardless of gender
• Your doctor expects you to live for more than 12 weeks
• You are generally able to carry out normal daily activities, or have only mild limitations due to your illness (confirm with trial site)
• You have been diagnosed with advanced or spreading kidney cancer (specifically the "clear cell" type) that is considered intermediate or high risk by your doctor
• You have at least one area of cancer that can be measured on a scan
• A biopsy or tissue sample from your tumor has tested positive for a protein called CD70
• You have already received at least one previous treatment for your kidney cancer, which must have included either a combination of two immunotherapy drugs targeting PD-1 and CTLA-4, or an immunotherapy drug combined with a targeted therapy aimed at blood vessel growth
• You have suitable veins for a blood collection procedure, and your blood counts (red cells, white cells, and platelets) meet minimum levels set by the trial
• Your kidneys, liver, heart, and lungs are working well enough to meet specific test thresholds set by the trial (confirm exact values with trial site)
• You are willing to take part voluntarily, have understood the study information, and have signed a consent form agreeing to follow all study procedures

Who may not be able to join:

• You have previously received a treatment that specifically targets CD70
• Your kidney cancer has spread to your brain
• You currently have another cancer that is not under control (some early-stage or surgically treated cancers may be exceptions — confirm with trial site)
• You have an active infection that is not controlled, or you have needed intravenous antibiotics or other infection treatments in the 14 days before joining the trial
• You have active hepatitis B, hepatitis C, HIV, or syphilis based on blood tests
• You have certain unstable or serious health conditions, such as recent heart attack or stroke (within the last 6 months), severe heart failure, poorly controlled diabetes, serious irregular heartbeat, or poorly controlled liver, kidney, or metabolic disease
• You are pregnant, currently breastfeeding, or planning to become pregnant within one year after receiving the treatment — or your partner is planning a pregnancy within that time (unless you are willing to use highly effective contraception throughout)
• You have previously been treated with CAR-T therapy or any other type of genetically modified cell therapy
• You have a cardiac pacemaker or a deep brain stimulator implanted
• You have received a live vaccine within 4 weeks before the blood collection procedure
• You have had an autoimmune disease (such as Crohn's disease, rheumatoid arthritis, or lupus) in the past 2 years that caused organ damage or required immune-suppressing medication
• You have a history of significant brain or nervous system conditions, such as seizures, stroke, severe brain injury, dementia, Parkinson's disease, or serious psychiatric disorders
• You are currently taking steroid tablets or injections and are expected to need them long-term during the study (inhaled or skin-applied steroids may be acceptable — confirm with trial site)
• You have a condition that would prevent you from understanding or signing the consent form, or from following the study requirements
• You have had a severe allergic reaction to any medication that would be used in this study
• Your doctor believes there is any other reason that makes it unsafe or unsuitable for you to take part

Important: Always verify eligibility with the trial site directly before applying.