Rare Disease Trial, Not Yet Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

For patients with a rare inherited or structural brain blood vessel condition (MVCR group):

• You are between 18 and 80 years old
• You have a confirmed diagnosis of a genetic brain blood vessel condition (such as CADASIL, or a condition linked to the COL4A1, COL4A2, or HTRA1 genes), OR a confirmed diagnosis of Moya-Moya disease, cavernoma, cerebral venous thrombosis, or another brain blood vessel malformation
• You are already enrolled in the MVCR patient group (confirm with trial site)
• You are covered by social security or an equivalent health insurance scheme
• You are willing and able to give written consent to participate

For healthy comparison volunteers (control group):

• You are between 18 and 80 years old
• Your blood pressure is below 140/90 mmHg without medication, or below 130/80 mmHg if you take blood pressure medication that has been stable for at least 3 months
• Your neurological examination is completely normal, with no signs of weakness or other focal problems
• Your memory and thinking assessment score is 26 or above out of 30 on a standard test (MMSE)
• You are covered by social security or an equivalent health insurance scheme
• You are willing and able to give written consent to participate

Who may not be able to join:

For everyone (both groups):

• You are pregnant, currently in labour, or breastfeeding
• You are under 18 years old
• You are currently deprived of your liberty (for example, held in custody) by a legal or administrative decision
• You are hospitalised without your consent and do not have a legal protection arrangement in place
• You are an adult under a legal guardianship or protection measure, or are unable to give consent yourself
• You are currently in a waiting or exclusion period from another research study
• You are already taking part in another interventional (hands-on) research study
• You have an active or long-term infectious disease

For healthy comparison volunteers (control group) only:

• You have any known brain or blood vessel condition in or around the brain that requires specific medical management
• You have a known heart or cardiovascular condition, such as coronary artery disease, arterial disease, atrial fibrillation, or heart failure
• You have a history of stroke, mini-stroke (TIA), bleeding in the brain, meningitis, encephalitis, or a head injury that caused loss of consciousness for more than 30 minutes
• You have multiple sclerosis, a neurodegenerative disease, or active epilepsy
• You are a current or former smoker with a significant smoking history (more than 10 pack-years) (confirm with trial site if unsure how this applies to you)
• You have diabetes
• You are taking blood-thinning medications or cholesterol-lowering medications

Important: Always verify eligibility with the trial site directly before applying.