Obesity Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• Adults aged 18 or older, of any gender
• People who have been diagnosed with recurring (repeat) depression, classified under the international disease code ICD-11 (6A71)
• People whose body weight falls into the overweight or obese range using the Asian measurement standard (BMI under 23)
• People who score at or above a certain level on standard depression questionnaires (BDI score of 13 or higher, or PHQ score of 4 or higher)
• People who have either never taken antidepressant medication, have been off antidepressants for at least 2 weeks before joining, or did not take antidepressants in the 7 days before joining — note that stopping a medication that is currently working, just to join this trial, is not permitted
• People taking non-psychiatric medications, provided that medication and dosage have been stable for at least 14 days before joining, with no recent changes in dose or frequency

Who may not be able to join:

• People under 18 years of age
• People with dementia or significant cognitive impairment that would prevent them from completing self-reported questionnaires
• People who have other health conditions such as high blood pressure or chronic kidney disease, if they are currently taking medication for those conditions (confirm with trial site)
• People who are employees, family members of employees, or otherwise personally connected to the research team or trial site
• People who have participated in another interventional clinical trial within the 6 months before this trial, or are currently in another trial
• People who have previously tried antidepressants included in this study without any benefit
• People who have given birth within the 6 months before joining, or who are currently breastfeeding
• People who have received ketamine, certain older antidepressants called irreversible MAO inhibitors (such as tranylcypromine), electroconvulsive therapy (ECT), or other stimulation-based treatments during their current episode of depression
• People diagnosed with dementia or assessed as having moderate to severe general cognitive impairment
• People who meet clinical criteria for alcohol use disorder or substance use disorder, or whose drug screening test comes back positive (except for benzodiazepines or opiates)
• People with a known allergy or medical reason to avoid the antidepressants used in the study
• People with a history of suicidal tendencies
• People with uncontrolled liver, kidney, or heart disease
• People with diabetes
• People with untreated underactive thyroid (hypothyroidism)
• People with a history of heart attack or stroke
• People with symptomatic peripheral arterial disease (reduced blood flow to the limbs causing symptoms)
• People with a hereditary condition causing very high cholesterol levels (monogenic familial hypercholesterolemia)

Important: Always verify eligibility with the trial site directly before applying.