Phase 4 Uveitis Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are 18 years of age or older (any gender)
• You have been diagnosed with active, non-infectious uveitis (inflammation inside the eye) affecting the middle, back, or entire eye, with signs of active inflammation confirmed by an eye doctor
• You have been taking oral steroid tablets (such as prednisone) at a dose between 10 mg and 60 mg per day for at least 2 weeks before the screening visit, and are still on the same dose
• You are willing to agree to not become pregnant, cause a pregnancy, or donate sperm during the entire trial and for 6 months after it ends, and will use effective contraception
• Your doctor has assessed the risks and benefits and has prescribed you the study medication (adalimumab)
• You are willing and able to sign a consent form agreeing to have your data collected and used for this study

Who may not be able to join:

• You have certain types of eye conditions, such as: uveitis only at the front of the eye; suspected or confirmed eye infection; eye cancers (such as eye lymphoma); certain other specific eye diseases; significant cloudiness in the cornea or lens; very high eye pressure not well controlled by 2 or more glaucoma medications; very poor vision (below a certain level) in either eye; advanced diabetic eye disease; wet macular degeneration; or if you have had eye surgery within the past 90 days (some minor procedures may be exceptions — confirm with trial site)
• You have, or have had in the past, a disease affecting the nerve coverings in the brain or spine (such as multiple sclerosis or optic neuritis)
• You have, or have had, lupus (a disease where the immune system attacks the body)
• You have a significant heart rhythm problem or moderate-to-severe heart failure
• You have recently had a stroke or another serious medical condition that the doctor feels makes participation risky
• You have or have had any cancer, except for certain successfully treated skin cancers or a very early-stage cervical condition (confirm with trial site)
• You are allergic to the active ingredient in the study drug or similar medications
• You have a body-wide inflammatory disease that requires ongoing steroid or immune-suppressing treatment
• You have had a serious infection needing IV antibiotics in the last 30 days, or an infection needing oral antibiotics in the last 14 days
• Your dose of certain immune-suppressing medications (such as methotrexate, cyclosporine, or others) was increased in the last 30 days, or your current doses are above set limits (confirm with trial site)
• You received a live vaccine (such as MMR or chickenpox vaccine) within the past 3 months, or plan to receive one during the study
• You received certain injections into the eye (such as anti-VEGF drugs like ranibizumab or aflibercept) within the past 90 days
• You received a methotrexate injection into the eye within the past 90 days
• You had a specific steroid eye implant (Ozurdex/dexamethasone implant) within the past 6 months
• You have been treated with anti-TNF medications or certain other uveitis treatments within the past 6 months
• You are currently taking part in another clinical trial
• Your doctor does not feel it is appropriate or safe for you to participate

Important: Always verify eligibility with the trial site directly before applying.