Brain Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• Adults aged 18 or older
• People whose ability to carry out daily activities meets a minimum level, as measured by a standard medical scale called the Karnofsky Performance Status (score of 70 or above)
• People who have been diagnosed with a specific type of brain tumour called IDH-wildtype glioblastoma, confirmed through laboratory testing of tumour tissue
• People whose glioblastoma has come back for the first, second, or third time
• People whose tumour recurrence has been identified on brain scans using a specific set of assessment guidelines called RANO 2.0
• People who have previously received radiotherapy and a chemotherapy drug called temozolomide for this condition
• People for whom at least 6 months have passed since their last course of radiotherapy
• People who have a returning tumour that shows up clearly on an MRI scan with contrast dye
• People whose returning tumour measures no more than 5 cm at its widest point
• People for whom molecular test results for their tumour are available, including IDH and MGMT status
• People whose blood, kidney, and liver function results are within an acceptable range
• People who are able and willing to provide written informed consent to participate

Who may not be able to join:

• People who have previously been treated with a drug called bevacizumab
• People for whom chemotherapy or targeted drug therapy is planned following the study treatment
• People who have previously had a specialised form of focused radiotherapy (stereotactic re-irradiation) in the same area of the brain being targeted in this trial
• People whose tumour has come back more than three times
• People living with significant psychiatric conditions
• People with significant neurological conditions unrelated to their brain tumour
• People who have an implanted device such as a pacemaker, defibrillator, deep brain stimulator, or any other electronic implant that may be incompatible with the study procedures
• People who are pregnant or breastfeeding
• People with active bleeding inside the brain
• People with high blood pressure that is not well controlled
• People with severely reduced kidney function
• People already taking part in another clinical study that is likely to interfere with this one

Important: Always verify eligibility with the trial site directly before applying.