Phase 1 Obesity Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who are in good general health, with no significant medical history, and whose blood tests, urine tests, and vital signs come back normal at the screening visits
• People who are between 18 and 60 years old at the time of screening
• People whose body mass index (BMI — a measure of weight relative to height) falls within a specific range: between 25 and under 35 for one part of the study, or between 27 and under 40 for another part, at the time of screening
• People who are able to communicate clearly with the research team, follow the study requirements (including staying at the study site for required periods), and provide written consent

Who may not be able to join:

• People who have any condition that, in the investigator's opinion, could affect their safety, the study results, or their ability to follow the study rules
• People who have used a GLP-1 receptor agonist medication (a type of drug used for blood sugar or weight management) within 90 days before screening
• People who have used any medication for obesity within the 90 days before screening
• People who report a change in body weight of more than 5 kg (11 lbs) in the 90 days before screening
• People who have previously had, or plan to have during the trial, surgery or a medical device used for weight loss
• People whose HbA1c (a blood test measuring average blood sugar levels) is 6.5% or higher at screening
• People with a personal history of type 1 or type 2 diabetes
• People with a history of heart block, an abnormal heart electrical reading (ECG), or a specific electrical interval in the heart (PR interval) over 200 milliseconds that the investigator considers a risk
• People with a significant history of, or current, heart, lung, liver, kidney, digestive, hormonal, blood, or neurological conditions that could affect how the body processes the study drug or affect the safety or results of the study
• People whose kidney filtration rate (a measure of how well the kidneys work) is below 80 mL/min at screening
• People with a personal or family history of a specific type of thyroid cancer (medullary thyroid carcinoma) or a related inherited condition (multiple endocrine neoplasia syndrome type 2)
• People who have had acute pancreatitis (sudden inflammation of the pancreas) in the 90 days before screening, or who have a history of chronic pancreatitis
• People with an active cancer or a history of cancer in the past 5 years, with the exception of certain minor skin cancers that have been fully removed or resolved
• Women who are pregnant, breastfeeding, planning to become pregnant, or who could become pregnant and are not using a highly effective form of contraception
• People who have taken any prescription medications (other than hormonal contraceptives that prevent ovulation) within 14 days of screening
• People who have already taken part in a different dose group within this same study
• People with a known allergy or sensitivity to semaglutide (the drug being studied)
• People with known or suspected alcohol or substance misuse in the year before screening, or who test positive for drugs or alcohol at screening or on Day -1
• People who test positive for HIV, or have active hepatitis B or hepatitis C infection at screening
• People with extensive tattoos, significant skin marks, or excessive body hair near the area where a study patch would be applied
• People who have taken part in another clinical trial, or used an investigational drug or device, within 30 days or 5 half-lives (whichever is longer) before screening, or who plan to join another clinical trial while in this study
• People who have donated or lost more than 200 mL of blood in the 60 days before Day -1, donated plasma within 7 days before Day -1, or plan to donate blood or plasma during the study
• People who work at the study site, are an immediate family member of someone who does, are employed by the study sponsor (Terrestrial Bio), or are an immediate family member of a Terrestrial Bio employee

Important: Always verify eligibility with the trial site directly before applying.