Phase 2 Non-Alcoholic Fatty Liver Disease Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People aged 18 to 45 years of any gender.
• People who have been diagnosed with Metabolic Associated Fatty Liver Disease (MAFLD), which requires evidence of fat in the liver shown by at least one of: an ultrasound, CT scan, or MRI showing liver fat of 5% or more; a liver biopsy taken within the last 6 months confirming fat in the liver of 5% or more; or a FibroScan result (a specific liver measurement) at or above a certain threshold (confirm with trial site).
• People who also have at least one sign of metabolic health issues, such as: a higher-than-average body weight or waist size; elevated blood pressure or being on blood pressure medication; pre-diabetes, Type 2 diabetes, or certain elevated blood sugar readings; high levels of fats called triglycerides in the blood, or being on cholesterol-lowering medication; or low levels of "good" (HDL) cholesterol, or being on cholesterol-lowering medication.
• People who take medications for blood sugar, blood pressure, or cholesterol must have been on a stable, unchanged dose for at least 3 months before the trial screening.
• People whose body weight has been stable — meaning it has not changed by more than 5% — in the 3 months before screening and between screening and enrolment.
• People who are willing to take part voluntarily, attend follow-up appointments, and sign a consent form.

Who may not be able to join:

• People with significant liver function problems, based on specific blood test results being more than twice (or in some cases 1.5 times) the normal upper limit (confirm with trial site).
• People who have used certain medications known to cause liver fat or scarring — such as steroids, valproate, methotrexate, tamoxifen, amiodarone, or oral vitamin E — for more than 2 weeks in the past year.
• People who drink a large amount of alcohol each week — above certain limits depending on gender (confirm with trial site for exact amounts).
• People who test positive for Hepatitis B or Hepatitis C.
• People who have certain other liver conditions or health conditions that can themselves cause a fatty liver, such as autoimmune hepatitis, Wilson's disease, inflammatory bowel disease, coeliac disease, an underactive thyroid, or several other specific conditions (confirm with trial site for the full list).
• People with a history of low white blood cell counts (a condition affecting the immune system).
• People who have had weight-loss (bariatric) surgery within the past 2 years.
• People who are pregnant, planning to become pregnant, or currently breastfeeding.
• People with a history of cancer, heart disease, chronic kidney disease, advanced liver scarring with complications, or a liver transplant.
• People who have taken any antibiotics within the 2 weeks before joining the trial.
• People whom the clinical investigator considers unsuitable for the study for any reason.

Important: Always verify eligibility with the trial site directly before applying.