Obesity Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• Healthy men and women who are using contraception during the study and for 3 months after it ends
• People aged between 18 and 65 years old at the time of signing the consent form
• People with a body mass index (BMI) either between 18.5 and 25, or between 30 and 35 (confirm with trial site which range applies)
• People who are willing and able to take part in the full study, including drinking a special sugar drink containing a tracer substance called 14C-glucose and eating the meals provided
• People who have regular bowel movements, meaning they typically have between 1 and 3 stools per day
• People who normally eat three meals a day — breakfast, lunch, and dinner

Who may not be able to join:

• People who have been diagnosed with any type of diabetes (Type 1, Type 2, or a genetic form)
• People who have been diagnosed with heart disease or high blood pressure (readings of 140 mmHg or higher on the top number, and/or 90 mmHg or higher on the bottom number)
• People with a blood sugar control reading (HbA1c) higher than 53 mmol/mol
• People with a significant history of heart, kidney, liver, breathing, gut, immune system, hormonal, nerve, or mental health conditions
• People who have been diagnosed with a breathing condition such as COPD or asthma
• People with a history of movement disorders or problems with muscle or fat metabolism
• People with known severe kidney problems
• People with a stomach or gut ulcer, or a strong history of indigestion
• People with a recent or ongoing history of diarrhoea
• People with known anaemia (low iron or low red blood cells)
• People with a personal or family history of blood clots, epilepsy, seizures, or schizophrenia
• People who regularly use dietary supplements more than 3 times per week
• People who regularly take any prescribed or over-the-counter medications (except contraceptives or contraceptive devices)
• People with a history of drug or alcohol misuse in the past two years
• People who test positive for alcohol at the screening or admission appointment
• People who use recreational drugs
• People who experience claustrophobia (fear of enclosed spaces)
• People who are currently following a weight-loss diet or a high-calorie or high-protein diet aimed at gaining weight
• People with ongoing constipation
• People with known allergies or intolerances to any of the 14 major food allergens — celery, gluten-containing grains, crustaceans, eggs, fish, lupin, milk, molluscs, mustard, tree nuts, peanuts, sesame seeds, soybeans, or sulphur dioxide/sulphites — or a history of conditions affecting nutrient absorption, including coeliac disease
• People who regularly experience gut problems such as abdominal pain, stomach upsets, or loud bowel sounds, or who have known or suspected irritable bowel syndrome
• People who are currently taking part in another research study
• People who have received a product containing the tracer substance 14C in the past 12 months
• People who are pregnant or breastfeeding
• People who currently smoke or who have used nicotine-containing products in the 6 months before the study
• People who have taken antibiotics in the 60 days before the study's preparation period begins
• People who are currently following a structured, progressive resistance training programme more than 3 times per week
• People assessed as having a sedentary (very inactive) lifestyle based on the International Physical Activity Questionnaire (IPAQ)
• People who are unable to give informed consent
• People who are employed by, or completing a thesis or internship at, the department of Human and Animal Physiology linked to this trial

Important: Always verify eligibility with the trial site directly before applying.