Phase 2 Sickle Cell Disease Trial, Recruiting NCT07708714 Sponsor: Children's Hospital Medical Center, Cincinnati Condition: Sickle Cell Disease
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Phase 2 Sickle Cell Disease Trial, Recruiting

NCT07708714
Recruiting Phase 2

Who may be able to join

AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI

Who might be able to join this trial:

  • People aged 11 to 18 years old who have been diagnosed with sickle cell anaemia (a serious inherited blood disorder)
  • People who are already taking part in a related study called the NOHARM MTD Study at the Mulago Hospital Sickle Cell Clinic and have agreed to continue into this extension study
  • People aged 11 to 18 years old with confirmed sickle cell anaemia who have never taken a medicine called hydroxyurea, and who live in Kampala or the surrounding areas (this group will be enrolled as a comparison group)

Who may not be able to join:

  • People who are outside the age range of 11 to 18 years old
  • People who have not been confirmed as having sickle cell anaemia
  • People joining the comparison group who have previously taken hydroxyurea

Important: Always verify eligibility with the trial site directly before applying.

Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.

This is a simplified plain English summary of the eligibility criteria. Full criteria are set by the trial investigators and may include additional requirements not shown here. Never self-exclude from a trial based on this summary. Contact the trial site directly to confirm your eligibility.
Last synced 27 July 2026
Phase 2: approximately ~30% of drugs entering this phase reach regulatory approval, based on published industry-wide historical data. This is not specific to this trial.
Phase success rates shown are historical industry-wide averages based on published data. They are not a prediction for this specific trial or your individual situation.

Contact this trial

Principal Investigator: Russell E. Ware, MD, PhD, Children's Hospital Medical Center, Cincinnati

Phone: 5138037922

Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.

GP referral letter

Print a one-page summary to share with your doctor.

Trial details

Status
Recruiting
Phase
Phase 2
Registry
ClinicalTrials.gov
Start date
13 May 2026
Est. completion
30 November 2030

Where this trial is recruiting

Uganda

Primary endpoints

Composite measure of organ damage

Can't join this trial?

Expanded access pathways

If this trial is not available to you, other access pathways may exist. In Australia, the TGA Special Access Scheme allows access to unapproved therapeutic goods for individual patients.

TGA Special Access Scheme information

Find other recruiting trials on ClinicalTrials.gov

Data last synced from ClinicalTrials.gov: 27 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.

Trial recruitment status can change without notice between our nightly data updates. Always contact the trial site directly to confirm current recruitment status before making any decisions or travel arrangements.

View original record on ClinicalTrials.gov