Phase 3 Spinal Muscular Atrophy Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have been diagnosed with prostate cancer (a specific type called adenocarcinoma, without small cell features), confirmed through a tissue or cell sample
• People whose cancer has continued to grow or spread despite having their testosterone lowered through surgery or medication, and after receiving a treatment called abiraterone acetate (either for metastatic hormone-sensitive or early castration-resistant prostate cancer)
• People whose cancer has spread to the bones (visible on a bone scan) or to soft tissues (visible on a CT or MRI scan)
• People who are relatively well and able to carry out everyday activities, rated 0 or 1 on a standard medical scale called the ECOG performance scale
• People whose organs (such as kidneys and liver) are functioning at an adequate level based on blood tests

Who may not be able to join:

• People who have previously received certain prostate cancer treatments, including chemotherapy, radioligand therapy (such as lutetium-177 PSMA or radium-223), specific hormone-blocking drugs (apalutamide, darolutamide, or enzalutamide), PARP inhibitors used alone, or other systemic cancer treatments such as immunotherapy, antibody therapy, or gene/cell therapy — with two exceptions: (1) older-generation anti-hormone drugs (such as bicalutamide, flutamide, or nilutamide) are allowed if stopped before the first study dose, and (2) docetaxel chemotherapy is allowed if it was given for hormone-sensitive metastatic disease and the cancer did not progress during or within 3 months of finishing it
• People who have received any other cancer treatment (drug or vaccine) within 28 days or 5 half-lives of the drug — whichever period is longer — before being enrolled (confirm with trial site)
• People who have cancer that has spread to the brain, or who have active cancer involvement of the lining around the brain and spinal cord
• People with significant heart or blood vessel disease (confirm with trial site for full details)
• People with a serious medical condition, active infection (bacterial, fungal, or viral), or a psychiatric condition — including suicidal thoughts or behaviour within the past year — that in the treating doctor's judgment could increase the risk of participation or make the person unsuitable for the trial
• People with active inflammatory bowel disease, ongoing chronic diarrhoea, or who have previously had stomach removal surgery or lap-band surgery

Important: Always verify eligibility with the trial site directly before applying.