Phase 2 OCD Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have been diagnosed with OCD (Obsessive-Compulsive Disorder) according to standard medical guidelines, with symptoms lasting more than 1 year
• People whose OCD symptoms score above a certain level of severity on a standard OCD rating scale (Y-BOCS score greater than 16)
• People currently taking medication for OCD, where the dose has remained unchanged for at least 3 weeks before the study begins and stays the same throughout, and who remain under the care of their psychiatrist for the whole study
• People aged between 22 and 80 years old on the day they sign the consent form
• People who are able and willing to have a brain MRI scan
• People who are able and willing to wear a specific head device (called an Attune device) during the study sessions
• People who are able to read, understand, and sign a consent form as required by local rules, after the study has been fully explained to them
• People who can speak, read, and understand the language used by the trial staff and in the consent form
• People who can respond verbally to questions, follow instructions, and complete the study tasks
• People who are able to follow the treatment schedule and attend all required visits
• People who a doctor determines to be medically stable at the start of the study, based on medical history and a basic physical check
• Male participants who agree to use a condom during all sexual activity and follow acceptable contraception methods with their female partner for the entire study period, and who agree not to father a child or donate sperm during this time
• Female participants who are sexually active and agree to use two forms of contraception for the duration of the study, or who are not able to become pregnant because they have gone through natural menopause (aged 45 or older with at least 6 months without a period), have had a hysterectomy, have had their fallopian tubes tied, or have had both ovaries removed with at least 6 weeks passed since that surgery

Who may not be able to join:

• People with a current or past diagnosis of bipolar disorder (type I or II), schizophrenia or other psychotic disorders, borderline personality disorder, or Tourette's disorder
• People who have had active suicidal thoughts, a suicide attempt, or self-harming behaviour in the past 6 months
• People who have previously had deep brain stimulation or brain surgery to remove or destroy brain tissue
• People with a history of substance or alcohol misuse disorder in the past 6 months (not including caffeine or nicotine)
• People with a history of traumatic brain injury involving loss of consciousness, seizures, or other neurological conditions
• People who have any reason they cannot safely have a brain MRI scan, or whose head does not fit within the MRI head coil while wearing the study device
• People who have received ketamine treatment or TMS (Transcranial Magnetic Stimulation) within one month before joining the study
• People with any medical or psychiatric conditions that could interfere with study activities or make the results difficult to interpret
• People with an uncontrolled or ongoing significant medical condition within the past 3 months — this includes but is not limited to diabetes, high blood pressure, HIV or other relevant infections, thyroid or hormonal disorders, COPD, confusion or delirium, heart failure, chest pain (angina), heart or digestive disease, kidney disease requiring dialysis, or active cancer
• People who have had major surgery (such as abdominal, chest, heart, or bone surgery, or any surgery requiring general anaesthetic) within the past 3 months
• People with a history of hepatitis or liver disease that the doctor considers to have been active within 6 months before the first visit
• People who are pregnant, trying to become pregnant, or currently breastfeeding
• People who are themselves, or have an immediate family member (such as a spouse, parent, sibling, or child) who is, a staff member directly involved in running this trial
• People with a Body Mass Index (BMI) above 34 kg/m²

Important: Always verify eligibility with the trial site directly before applying.