Eczema Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• All participants must have a regular doctor or primary care professional who will continue their usual care and can receive updates and recommendations from the research team.
• Group 1 (Healthy Adults): People who are male or female, aged 18 to 50 years at the time of joining.
• Group 2 (Adults with Atopic Dermatitis/Eczema): People with a confirmed diagnosis of atopic dermatitis (eczema), a moderate to severe level of the condition (measured by a scoring system called SCORAD, with a score of 25 or above), and at least one affected area in the crook of the arm or behind the knee at the time of joining.
• Group 3 (Healthy Children): Males or females aged 2 to 18 years.
• Groups 4, 5, and 6 (Patients with specific immune conditions including AD, HIES, WAS, or DOCK8 deficiency): People with a diagnosis of one of these conditions confirmed through genetic testing, with or without eczema-like skin symptoms.

Who may not be able to join:

• People who are currently receiving, or are planning to receive, certain experimental treatments, ultraviolet light therapy, monoclonal antibody therapy, or medicines that suppress the immune system within 7 days or 5 half-lives of starting the trial (whichever is the longer period).
• People who have or have had cancer and have received chemotherapy or radiation treatment within the past 6 months.
• People who have a history of bone marrow transplant or gene therapy.
• Group 2 (Eczema patients specifically): People who are unable to stop taking oral antibiotics or oral steroids for at least 7 days before skin sampling, or who are unable to stop using topical steroids or certain skin creams (calcineurin inhibitors) on the specific small areas of skin to be sampled for at least 7 days beforehand.
• Group 2 (Eczema patients specifically): People who have an underlying immune system deficiency, whether present from birth or caused by a medical treatment.
• Groups 4, 5, and 6 (HIES, WAS, DOCK8 patients specifically): People who are unable to stop using topical steroids and moisturisers for preferably 7 days, but at a minimum 24 hours, before skin sampling.
• Groups 1 and 3 (Healthy volunteers and healthy children specifically): People with unstable, uncontrolled, or ongoing medical conditions that require treatment or hospitalisation (the research doctor will assess this on a case-by-case basis).
• Groups 1 and 3 specifically: People with an underlying immune system deficiency, whether present from birth or caused by a medical treatment.
• Groups 1 and 3 specifically: People with a known ongoing skin condition such as eczema or psoriasis that could affect the study results (common short-term conditions like acne are generally permitted).
• Groups 1 and 3 specifically: People who work directly in healthcare, live in healthcare or assisted living facilities, homeless shelters, jails, or prisons, or who have frequent contact with laboratory animals.
• Groups 1 and 3 specifically: People who have asthma.
• People who are female and have symptoms or hormone levels indicating they are going through perimenopause (the transition period before menopause).

Important: Always verify eligibility with the trial site directly before applying.