Eczema

**Who might be able to join this trial:** - You have been diagnosed with atopic dermatitis (eczema), confirmed by having itchy skin in the past 12 months plus at least three of the following: eczema in skin folds (like behind the knees or inside the elbows), a personal history of asthma or hay fever, generally dry ski...

**Who might be able to join this trial:** - You previously took part in a clinical trial of dupilumab for eczema (atopic dermatitis) and completed the required visits and assessments in that trial - You previously received dupilumab in a specific type of trial that has finished, even if you didn't participate for the...

**Who might be able to join this trial:** - You are 18 years old or older (or older if the legal adult age in your country is higher) - You have had chronic eczema (atopic dermatitis) for at least 2 years before your visit - Your eczema scores at least 12 on a standard medical scale that measures how much of your body...

Who might be able to join this trial: - You are 12 years of age or older and weigh at least 40 kg (about 88 pounds) - You have been diagnosed with atopic dermatitis (eczema) for at least 1 year, and your symptoms are currently moderate to severe (based on specific scoring measurements the trial team will assess) - You...

**Who might be able to join this trial:** - You are 18 years old or older (or at least 12 years old, depending on where the trial is taking place and if it is allowed in your area) - You have been diagnosed with atopic dermatitis (eczema) and your symptoms started at least 2 years before joining the trial, and your dia...

**Who might be able to join this trial:** - You are 18 years old or older - You have been diagnosed with atopic dermatitis (eczema) using a specific set of recognised medical criteria - You have had atopic dermatitis for at least 1 year - Your atopic dermatitis affects between 5% and 50% of your body surface area (not...

Who might be able to join this trial: - You are between 12 and 17 years old and weigh at least 40 kg (about 88 lbs) - You have been diagnosed with atopic dermatitis (eczema) for at least 1 year, and your symptoms are currently moderate to severe based on specific medical scores measuring skin involvement, redness, and...

**Who might be able to join this trial:** - You are 18 years of age or older - You have been diagnosed with long-term (chronic) atopic dermatitis (eczema) for at least 6 months - Your eczema is considered moderate to severe, based on scores measured by your doctor across several standard rating scales (confirm with tri...

**Who might be able to join this trial:** - You are legally able to make your own decisions and sign a consent form - You are 18 years old or older - You have been diagnosed with chronic hand eczema that has either lasted more than 3 months, or has come back at least twice in the past 12 months, and has been generally...

**Who might be able to join this trial:** **For people coming from a related ("parent") lebrikizumab study:** - People who previously received treatment in one of the specified lebrikizumab parent studies (NCT04146363, NCT04178967, NCT04250337, or NCT04250350) and fully completed that study's treatments and final visi...

Who might be able to join this trial: - You are 18 years old or older at the time of screening. - You have been diagnosed with chronic atopic dermatitis (eczema). - You have had atopic dermatitis for at least 1 year before the start of the trial. - In the last 6 months, creams or ointments applied to the skin have not...

**Who might be able to join this trial:** - You have had atopic dermatitis (eczema) for at least 3 years before the start of the study, and your condition meets a standard set of diagnostic criteria for eczema (confirm with trial site). - Your eczema is currently rated as moderate to severe based on specific medical s...

**Who might be able to join this trial:** - You have been diagnosed with chronic atopic dermatitis (eczema) with symptoms that started at least 3 years before the study begins, and your condition meets a specific set of recognised diagnostic guidelines (confirm with trial site). - Your eczema is rated as moderate to se...

**Who might be able to join this trial:** - You are 18 years old or older (or the legal adult age in your country) and have been diagnosed with atopic dermatitis (eczema) for at least 12 months - Your eczema has not responded well enough to medicated creams or ointments (such as steroid creams, with or without other p...

**Who might be able to join this trial:** - You are 18 years old or older (note: in Korea, you must be 19 or older) - You have been diagnosed with atopic dermatitis (eczema) using standard medical criteria - You have had atopic dermatitis for at least 2 years - Your atopic dermatitis has been rated as "moderate" by a...

**Who might be able to join this trial:** - You have a confirmed food allergy (such as to peanut, hazelnut, walnut, cashew, milk, egg, soy, wheat, sesame, or shellfish/fish) proven by a skin or blood test or food challenge, AND a specific blood level (total IgE ≥ 400 IU/mL) at your screening visit - You have been diag...

**Who might be able to join this trial:** - Adults aged 18 years or older - People who have been diagnosed with chronic atopic dermatitis (eczema) for at least 6 months before the start of the trial, with the diagnosis confirmed by a photograph - People whose eczema has not responded well enough to standard treatments...

**Who might be able to join this trial:** - You are at least 12 years old at the time of signing the consent form - You have been diagnosed with atopic dermatitis (eczema) for at least 1 year, based on standard medical guidelines - You have previously tried a biologic medication or a JAK inhibitor pill for atopic derma...

**Who might be able to join this trial:** - The person weighs at least 10 kg, and both their weight and height are above the 5th percentile for their age on standard growth charts at the start of the trial. - The person has been diagnosed with Atopic Dermatitis (eczema) based on recognised medical criteria, with sympt...

Who might be able to join this trial: - The child is between 3 months and 3 years old - The child has been diagnosed with eczema (also called atopic dermatitis) by a specialist children's skin or immune system doctor - The child's eczema is rated as almost clear, mild, or moderate by the doctor, and scores above a cert...

**Who might be able to join this trial:** **For all parts of the trial:** - Women of childbearing potential must have a negative pregnancy test - People who are willing to avoid alcohol for 24 hours before each study visit - People who are non-smokers, light current smokers (5 or fewer cigarettes per day), or former s...

Who might be able to join this trial: - People aged 2 years or older at the time of giving consent to take part - People who have been diagnosed with atopic dermatitis (eczema) using a recognised set of medical criteria, with a history of the condition lasting at least 6 months (or at least 3 months for children under...

**Who might be able to join this trial:** - People aged 18 to 70 years old at the time of signing the consent form - People who weigh at least 50 kg and have a body mass index (BMI) between 18.5 and 35.0 - People who are in good general health, as assessed by the study doctor based on medical history, physical examina...

**Who might be able to join this trial:** - A doctor has confirmed a diagnosis of atopic dermatitis (eczema) that has not been adequately controlled with creams or ointments applied to the skin. - Eczema severity scores at the screening and randomization appointments must meet specific thresholds set by the trial (con...

**Who might be able to join this trial:** - (Part 1) Healthy men, or women who cannot become pregnant, between 18 and 55 years old - (Part 2) Men, women who cannot become pregnant, or women who have had their tubes tied or removed, between 18 and 65 years old, who also have at least 2 of these symptoms: blocked/stuffy...

Who might be able to join this trial: - You are 18 years of age or older - You are able and willing to sign a form giving your permission to take part in the study - You have been diagnosed with CTCL (a type of skin lymphoma, which is a cancer affecting the skin) - You have been diagnosed with either atopic dermatitis...

Who might be able to join this trial: - All participants must have a regular doctor or primary care professional who will continue their usual care and can receive updates and recommendations from the research team. - **Group 1 (Healthy Adults):** People who are male or female, aged 18 to 50 years at the time of joinin...

**Who might be able to join this trial:** *For healthy volunteers (some cohorts now closed or inactive — confirm current status with trial site):* - Adults between 18 and 50 years old at the time of first study samples are taken. - People who are also enrolled in a related NIH study (protocol 08-HG-0059). - People who...

**Who might be able to join this trial:** - Adults over 18 years old who have been diagnosed with severe atopic dermatitis (eczema), based on a specific severity score above 40 - People whose eczema has been ongoing and stable for more than one year - People who have previously tried light therapy or one or more immun...

**Who might be able to join this trial:** - You are between 2 and 99 years old if attending in person at the NIH Clinical Center, or between newborn and 99 years old if participating by mail-in samples or telehealth visits - You are willing to allow samples (such as blood, saliva, cheek swabs, nasal swabs, and stool)...

Who might be able to join this trial: - You have been diagnosed with atopic dermatitis (eczema) based on UK working party diagnostic guidelines - Your atopic dermatitis is considered moderate to severe - Your skin condition scores above 20 on a standard measurement scale called the Objective SCORAD, OR you are currentl...

Who might be able to join this trial: - You are able to understand and sign a written consent form, and are willing and able to follow the study's requirements. - A dermatologist (skin doctor) has diagnosed you with a long-term inflammatory skin condition. - You are already receiving a systemic treatment (a medicine th...

Who might be able to join this trial: - Adults and children receiving new systemic (whole-body) treatments for atopic dermatitis (a type of chronic skin condition causing itchy, inflamed skin) may be invited to take part in this registry. Who may not be able to join: - People who are unable to complete questionnaires...

Who might be able to join this trial: - You have been diagnosed with atopic eczema (also called atopic dermatitis) based on a specific set of recognised diagnostic guidelines - You are starting a new treatment for your eczema, either a light-based therapy (such as UVB light treatment) or a medication that affects the i...

**Who might be able to join this trial:** - Be between 3 and 21 years old - Already be enrolled in a specific related NIH study called "Natural History and Genetics of Food Allergy and Related Conditions" (study 15-I-0162) - Have a blood test result showing a very high total IgE level (a marker related to allergies) of...

**Who might be able to join this trial:** - The baby must be born to a healthy mother who had a straightforward, uncomplicated pregnancy and delivered at full term (on time) - The mother can be of any ethnic or social background, but must be able to speak, read, and understand Swedish well enough to give consent - For...

Who might be able to join this trial: - People who have had continuous health insurance covering both medical care and prescription medications for at least 6 months before and up to their last menstrual period (the date used to estimate the start of pregnancy) - People who have a recorded diagnosis of atopic dermatiti...

**Who might be able to join this trial:** - People aged 13 to 65 (for psoriasis), or aged 13 and older (for eczema and normal skin), of any gender - People who are able to understand the study information and agree to take part - People who are able to attend clinic appointments and follow study procedures - People wh...

Who might be able to join this trial: - You are between 0 and 85 years old - You have been diagnosed with atopic dermatitis (a type of skin condition) and/or a related allergic condition, such as hay fever, allergic asthma, or a food allergy - You can continue any current treatments you are already receiving during the...

**Who might be able to join this trial:** - People aged 6 to 65 years old (male or female) - People who have been diagnosed with atopic dermatitis (eczema) according to standard medical diagnostic criteria **Who may not be able to join:** - People who are already enrolled in another clinical trial - People who have a...

Who might be able to join this trial: - You have been diagnosed with Atopic Dermatitis (eczema) based on recognised medical guidelines - You are able to give verbal consent to take part - You have valid social insurance coverage Who may not be able to join: - You have a personal history of asthma that is not well cont...

**Who might be able to join this trial:** - People who have a confirmed genetic diagnosis of a primary immune deficiency (a condition where the immune system does not work properly due to a gene change) - People who have a gene change that may affect immune function, or who have a history of infections that are unusual...

Who might be able to join this trial: - Women who are pregnant and between 18 and 45 years old - Women who are attending pregnancy check-ups at one of the selected clinics or hospitals involved in the trial - Women who are less than 12 weeks pregnant at the time of joining - Women who plan to continue attending check-u...

**Who might be able to join this trial:** **For all participants:** - Adults between 18 and 65 years old (inclusive) at the time of giving consent - People who are willing and able to give their informed consent before any study procedures begin - People who are willing to follow all study procedures and are available...

**Who might be able to join this trial:** - Children and teenagers aged 6 to 17 years old at the time of joining the trial. - People who have moderate to severe eczema (atopic dermatitis) that has not been well controlled with creams or ointments, and has been diagnosed by a skin or allergy specialist using a standard...

Who might be able to join this trial: - Adults aged 18 or older. - People who have been diagnosed with atopic dermatitis (a type of chronic skin condition causing itchy, inflamed skin) for at least one year. - People whose skin condition has not improved enough with creams or ointments applied directly to the skin. - P...

Who might be able to join this trial: - You have been diagnosed with moderate to severe atopic dermatitis (a serious form of eczema that causes inflamed, itchy skin). - Your doctor has determined that you need a systemic treatment (medication that works throughout the whole body, such as tablets or injections, rather t...

**Who might be able to join this trial:** - You have been diagnosed with atopic dermatitis (eczema) for at least 2 years, and this diagnosis has been confirmed at your screening visit using standard medical guidelines. - Your eczema is moderate-to-severe, covering more than 10% of your body, and a doctor has rated it...

Who might be able to join this trial: - You are 18 years of age or older (male or female) - You have been diagnosed with moderate to severe eczema (atopic dermatitis), confirmed by specific measurement scores checked at the start of the trial — including a skin severity score (EASI) of 16 or higher, a doctor's overall...

Who might be able to join this trial: - You are a patient from one of the approved medical units that has passed a data review by the National Clinical Center for Skin and Immune Diseases (confirm with trial site for the list of approved locations) - You have been diagnosed with a type 2 inflammatory skin disease, whic...

**Who might be able to join this trial:** - You are 12 years old or older and have been diagnosed with moderate to severe atopic dermatitis (a serious form of eczema) that has needed whole-body (systemic) treatments in the past - Your doctor has decided that starting treatment with Cibinqo (abrocitinib) tablets is appr...

**Who might be able to join this trial:** - You are generally healthy, apart from having atopic dermatitis (eczema) and possibly other related conditions like hay fever, eye allergies, or asthma - You are able to continue any current allergy or asthma medications (such as antihistamines, inhaled steroids, or similar t...

**Who might be able to join this trial:** - People of any age (from newborns to 99 years old) who are known to have, or are suspected of having, an inherited condition related to allergies, mast cells (a type of immune cell), or problems with how the immune system is regulated - Blood relatives of people who are alread...

**Who might be able to join this trial:** - Children between 8 and 17 years old - Children who understand and speak French - Children who have been diagnosed with atopic dermatitis (eczema), ranging from mild to severe - Children who have been referred by their doctor to the eczema education program at the Reunion Univ...

"Who might be able to join this trial: - You are a child or adult with atopic eczema (also known as atopic dermatitis) that is severe enough, or affects your quality of life enough, that your doctor is starting you on a specific type of strong medication (such as ciclosporin, azathioprine, methotrexate, or a newer biol...

**Who might be able to join this trial:** - People who are older than 18 years of age at the time of joining the trial. - People with a clinical diagnosis of moderate-to-severe chronic atopic dermatitis (also known as atopic eczema), where the treating doctor considers the treatment abrocitinib appropriate under its ap...

**Who might be able to join this trial:** - You are a woman of any age who is currently pregnant or have been pregnant within the last year - You are willing to take part and have signed and dated a consent form confirming you understand what the study involves - You agree to allow your healthcare provider(s) to share...

Who might be able to join this trial: - The child's parent or guardian must agree to take part and sign a consent form - The child must be 6 months old - The child must be generally healthy, with no significant medical conditions and no concerning findings from their health history or a physical check-up - The child mu...

Who might be able to join this trial: - People aged 12 years or older - People who have been diagnosed with atopic dermatitis (eczema) based on a specific set of recognised diagnostic guidelines called the UK Working Party's Diagnostic Criteria - People whose atopic dermatitis is considered moderate to severe, which ma...

Who might be able to join this trial: - You are 18 years of age or older - You have atopic dermatitis (eczema) that has been measured as moderate or severe using a standard scoring system called EASI, with a score of 7 or higher (confirm with trial site) Who may not be able to join: - You are known to be pregnant - Yo...

**Who might be able to join this trial:** - You are currently pregnant at the time you sign up - You live in the United States or Canada at the time you sign up - You give verbal agreement to take part in the OTIS Pregnancy Registry - You have been diagnosed with atopic dermatitis (eczema) at the time you sign up - Yo...

Who might be able to join this trial: - People who are adults (18 years of age or older) - People who have been diagnosed with atopic eczema (a chronic skin condition that causes itching and inflammation) - People who are currently receiving a medication called dupilumab at a dose of 300 mg every two weeks to treat the...

**Who might be able to join this trial:** - People who are at least 6 years old at the time of their first study visit. - People who are starting dupilumab treatment for the first time — for teenagers and adults (aged 12 and older) this applies to moderate-to-severe eczema, and for children aged 6 to 11 this applies to...

**Who might be able to join this trial:** - Adults aged 18 or older, of any sex - People with a documented history of moderate to severe eczema (atopic dermatitis) that has lasted for at least 1 year - People whose eczema has not responded well enough to prescription steroid creams or other prescribed topical treatment...

**Who might be able to join this trial:** - People who fully understand what the study involves, including its processes and possible side effects, and are able to sign a written consent form. - People aged 18 to 55 years old (inclusive) at the time of signing the consent form. - People with a body mass index (BMI) be...

**Who might be able to join this trial:** - Be at least 2 years old - Have a primary care doctor or provider located near where you live - Be able to speak and understand English (this can apply to a parent or caregiver who will be filling out questionnaires on behalf of the participant) - Have been diagnosed with ato...

**Who might be able to join this trial:** - Children and teenagers aged 1 to under 18 years old, of any sex, race, or ethnicity - A parent or legal guardian is able to provide signed consent, and the child can provide their own agreement to participate if appropriate for their age - The child has a diagnosis of atopic...

**Who might be able to join this trial:** - You are under 26 years old - A doctor has diagnosed you with atopic dermatitis (eczema) - If you are 18 or older, you are willing and able to sign a consent form yourself - If you are under 18, a parent or legal guardian is willing to sign a consent form on your behalf - You...

Who might be able to join this trial: - The patient must be between 6 and 17 years old - The patient must have moderate to severe atopic dermatitis (a skin condition causing redness and itching) and must be currently receiving or about to start receiving dupilumab injections given under the skin - A parent or guardian...

**Who might be able to join this trial:** - People aged between 12 and 17 years old at the time of their first study visit - People who have atopic dermatitis (eczema) and have been prescribed dupilumab under the Italian medicines authority (AIFA) reimbursement rules - People whose eczema severity score (EASI) is below...

Who might be able to join this trial: - People who have been diagnosed with moderate to severe atopic dermatitis (a skin condition) by a dermatologist or qualified healthcare provider. - People who are between 10 and 15 years of age at the time of joining. - People who have recently started, or are about to start, a sp...

**Who might be able to join this trial:** - Women who could become pregnant must have a negative pregnancy test at the screening visit and must agree to use highly effective contraception during the trial and for 6 months after the last dose of the study medication; men must agree to use a condom during the trial and...

Who might be able to join this trial: - You have been diagnosed with skin dermatitis (a type of skin inflammation or rash) - You are older than 9 years of age - You are able to come back for a follow-up visit one week after starting the study - You would be a suitable candidate for treatment with a cream/ointment calle...

**Who might be able to join this trial:** - Women between the ages of 15 and 50 who have been diagnosed with mild to moderate atopic dermatitis (a type of eczema). - People who are able to understand the study and are willing to formally agree to take part; for those under the legal age of adulthood, a parent or legal...

**Who might be able to join this trial:** **Food allergy only group:** - People who have been diagnosed by an allergist with a history of severe allergic reactions (anaphylaxis) to peanut, tree nut, egg, milk, or sesame. - People who have had skin prick testing and/or blood allergy testing for the relevant food within...

**Who might be able to join this trial:** - Children aged 6 months to under 12 years old at the time of screening - Children weighing at least 9 kg at screening - Children who have been formally diagnosed with atopic dermatitis (eczema) using a recognised set of diagnostic criteria - Children who have had atopic derma...

**Who might be able to join this trial:** - You are 18 years of age or older - You are willing and able to sign a consent form agreeing to take part in the study - You have been diagnosed by a skin specialist (dermatologist) with moderate or severe atopic dermatitis (eczema), based on one of the following: a skin sever...

Who might be able to join this trial: - People who have been diagnosed with Atopic Dermatitis (a type of skin condition involving dryness and itching), aged between 1 and 75 years old - People who are able to communicate in Chinese and have basic reading and writing skills - People (or their guardian, for younger parti...

**Who might be able to join this trial:** - People who have had chronic eczema (atopic dermatitis) for at least 3 years before the start of the study, and whose condition meets a recognised set of diagnostic standards known as the Hanifin and Rajka criteria. - People whose eczema is measured as moderate to severe at t...

**Who might be able to join this trial:** - Your eczema is rated at a score of 2 or higher on a standard medical scale that measures how much of the body is affected and how severe the symptoms are (confirm with trial site). **Who may not be able to join:** - Your eczema score is below 2 on the standard severity scale...

Who might be able to join this trial: - The child must currently be attending kindergarten. Who may not be able to join: - Children who have taken antibiotics at any point during the year before the study samples are collected may not be eligible. Important: Always verify eligibility with the trial site directly befo...

Who might be able to join this trial: - People who are male or female, aged between 18 and 65 years old at the time of giving consent. - People who weigh at least 40 kg at the time of their screening appointment. - People who have a doctor-confirmed diagnosis of moderate-to-severe atopic dermatitis (eczema), based on...

**Who might be able to join this trial:** - Adults, or teenagers aged 12 to 17 years old who weigh at least 40 kg, at the time of enrollment - People who have been clinically diagnosed with moderate to severe atopic dermatitis (a serious form of eczema) at the time of enrollment - People for whom a doctor has prescrib...

**Who might be able to join this trial:** - People who have been diagnosed with atopic eczema (either personally, or with a personal and family history of allergic conditions), of any severity level as classified by the UK health guidelines body NICE - People whose eczema severity score (measured using a standard scale...

**Who might be able to join this trial:** - You can read and understand English and are able to give your agreement to take part in English - You are a man or woman aged between 21 and 59 years old (inclusive) - You are generally healthy, with no ongoing health conditions and not taking any regular medicines - Your bod...

Who might be able to join this trial: - You are a man or woman in good general health - You are between 18 and 60 years old Who may not be able to join: - You are currently pregnant or breastfeeding - You use cannabis, opioids, or any other recreational drugs - You have a current or past diagnosis of a neurological, s...

**Who might be able to join this trial:** - The participant (or their parent or legal guardian, if applicable) must be able to understand and agree to take part in the study. - Participants must be male or female, aged 6 years or older. - Participants must have been diagnosed with active atopic dermatitis (eczema) acc...

**Who might be able to join this trial:** **Sub-Study 1 – Hidradenitis Suppurativa (HS) (a skin condition causing painful lumps):** - People who have been diagnosed with moderate-to-severe HS for at least 6 months before the study starts. - People who have never received a biologic medication for HS, or who tried an a...

**Who might be able to join this trial:** - You must be an adult aged 18 or over - You have a skin reaction (rash or irritation) caused by an allergy to metals - You experience body-wide allergic reactions triggered by metals - You are a healthy adult with no relevant conditions - You are able to read and sign a consen...

**Who might be able to join this trial:** - You currently have mild-to-moderate eczema (atopic dermatitis) in areas like the inside of your elbows or knees - You are between 21 and 65 years old (inclusive) - You can read and understand English and are able to give your consent in English - You live in Singapore and wil...

Who might be able to join this trial: - Pregnant women in Denmark who are before week 26 of their pregnancy - Women whose blood levels of certain omega-3 fatty acids (called EPA and DHA) measure below 4.7% of total fatty acids at the time of screening Who may not be able to join: - Women who are planning to take fish...

**Who might be able to join this trial:** - **Part 1 only:** You are between 18 and 55 years old at the time of signing the consent form - **Part 2 only:** You are between 18 and 70 years old at the time of your screening appointment - **Part 1 only:** You are in generally good health, confirmed by a full medical chec...

Who might be able to join this trial: - Women in Denmark who are pregnant and less than 26 weeks along at the time of joining - Women whose blood test shows that levels of two specific fatty acids (EPA and DHA) make up more than 4.7% of their total fatty acids - Women who are not currently taking more than the standard...

**Who might be able to join this trial:** - You are between 12 and 75 years old (male or female) - You have been diagnosed with atopic dermatitis (eczema) using a specific standard set of diagnostic criteria - Your eczema has lasted at least 1 year (if you are an adult) or at least 6 months (if you are a teenager) - Yo...

**Who might be able to join this trial:** - You are a woman who was 14 years old or older at the time your pregnancy ended - Your pregnancy occurred after September 21, 2021 (the date a cream called ruxolitinib was approved by the FDA) - You have at least one pharmacy record showing you were dispensed either ruxolitin...

Who might be able to join this trial: - Children and young people aged 6 years old up to (but not including) 18 years old - A parent or legal guardian who is able to understand and is willing to sign the consent forms on the child's behalf - People who have been diagnosed by a doctor with atopic dermatitis (eczema) usi...

**Who might be able to join this trial:** - People who have been diagnosed by a dermatologist with psoriasis, eczema, or chronic urticaria (a long-term hives condition) - People aged 16 or older - People whose itch has recently been at a level of 4 or higher on a scale of 0 to 10, where 10 is the worst possible itch -...

**Who might be able to join this trial:** - People who understand and are willing to sign a consent form, and who are able to attend regular visits and follow the study plan as required. - People aged 18 to 75 years old at the time of signing the consent form. - People who have been diagnosed with atopic dermatitis (a...

**Who might be able to join this trial:** - People aged 3 to 100 years old - People who have a suspected or confirmed allergy, atopic condition (such as eczema), breathing disorder, or nasal/sinus condition, OR a history of an immune system disorder - People who have had a past reaction — such as hives, swelling, or a...

**Who might be able to join this trial:** - Children aged 3 months to 12 years old, of any sex - Children with a skin tone classified as phototype I to IV (fair to olive skin tones — confirm with trial site) - Children who have atopic (dry, allergy-prone) skin and sensitive skin - Children who have had at least 3 ecze...

**Who might be able to join this trial:** - People aged 12 to under 18 years old, of any gender, who weigh at least 30 kg (about 66 pounds) - People who have been diagnosed with atopic dermatitis (AD) that meets a recognised set of medical standards, and who have had AD or eczema for at least 6 months before the scree...

**Who might be able to join this trial:** - You are between 18 and 75 years old - You have been diagnosed with chronic atopic dermatitis (also called atopic eczema) for at least 1 year - Your eczema has not responded well enough to standard skin creams or ointments, or those treatments are not suitable for you for medi...

Who might be able to join this trial: - The child must be between 6 and under 12 years old at the time of joining the study - The child must have been diagnosed with a long-term skin condition called atopic dermatitis (eczema) for at least 1 year before the screening visit - The child's eczema must be confirmed as mode...

Who might be able to join this trial: **For children joining from a previous related trial (Extension Cohort):** - Children aged 2 to under 12 years old who have already completed the full treatment phase of a qualifying earlier study related to this trial - Female participants must not be pregnant or breastfeeding, a...

**Who might be able to join this trial:** - You are 18 years old or older and have been diagnosed with moderate-to-severe atopic dermatitis (a serious form of eczema) - Your doctor has already prescribed you lebrikizumab as part of your normal treatment for your atopic dermatitis - You are willing and able to take part...

**Who might be able to join this trial:** - You have signed (or are willing to sign) a consent form agreeing to take part in the study. - You have moderate to severe atopic dermatitis (eczema), as assessed by the study doctor, AND either: your symptoms are poorly controlled (based on a standard questionnaire score), yo...

Who might be able to join this trial: - People aged between 18 and 65 years old, of any gender. - People who have been diagnosed with atopic dermatitis (eczema) according to a specific set of recognised medical diagnostic guidelines (the Hanifin & Rajka criteria). - People whose eczema affects less than 10% of their bo...

Who might be able to join this trial: - You have been diagnosed with type 1 diabetes - You currently use a diabetes device that attaches to your skin, such as an insulin pump or a continuous glucose monitor (CGM) Who may not be able to join: - You do not use any diabetes device that attaches to your skin - You are not...

**Who might be able to join this trial:** - You are between 18 and 75 years old (male or female) - You have been diagnosed with atopic dermatitis (a type of eczema) using a specific medical standard, and you have had eczema/atopic dermatitis for at least 1 year before joining the study - At the time of screening and th...

**Who might be able to join this trial:** - You are 18 years old or older - You have been diagnosed with moderate-to-severe atopic dermatitis (a significant form of eczema), confirmed by a specific score above 24 on a standard skin assessment scale - You are currently receiving, or have previously received, a systemic...

**Who might be able to join this trial:** - You are between 18 and 65 years old and have been diagnosed with long-term eczema on your hands, whether caused by internal factors (like skin sensitivity) or external triggers (like contact with certain substances) - Your hand eczema has been present for at least 3 months, o...

**Who might be able to join this trial:** - People who have had chronic atopic dermatitis (eczema) for at least 1 year before the study screening visit - People aged 12 years or older at the time of joining the study - People who have been diagnosed with moderate-to-severe atopic dermatitis by a certified skin special...

**Who might be able to join this trial:** - People who have had a confirmed diagnosis of atopic dermatitis (eczema) for at least 1 year before the screening visit, and for whom skin cream or ointment treatments have not worked well enough or are not suitable. - People whose eczema is rated moderate-to-severe, covering...

**Who might be able to join this trial:** - You are 18 years old or older - You do not object to taking part in the trial - You have been diagnosed with atopic dermatitis (eczema) for more than 6 months **Who may not be able to join:** - You are unable to fill in questionnaires due to physical or mental health difficu...

**Who might be able to join this trial:** **Phase 1b:** - People aged 18 or older at the time of signing consent - People with mild-to-moderate atopic dermatitis (eczema), where the affected skin covers 10% or less of the body - People whose eczema severity has been rated at a score of 3 or lower on a standard doctor-...

**Who might be able to join this trial:** - Men and women aged 18 years or older, of any ethnicity - People with skin tones ranging from fair to medium-olive (skin phototypes II to IV) - People with any skin type, whether sensitive or not - People currently experiencing an eczema flare-up of moderate severity (a skin s...

Who might be able to join this trial: - People who have had atopic dermatitis (a type of chronic skin condition, also called eczema) for at least 3 years before the start of the trial - People whose condition meets a recognised set of medical guidelines for diagnosing atopic dermatitis, known as the UK Working Party cr...

**Who might be able to join this trial:** - A parent or legal guardian has agreed to take part by signing a consent form - The baby was born at full term (at least 37 weeks of pregnancy) - The baby weighed between 2.5 kg and 4.5 kg (approximately 5.5 to 9.9 lbs) at birth - The baby is no more than 14 days old when join...

**Who might be able to join this trial:** **For Parts A, B, and C (earlier study phases):** - Men and women between 18 and 45 years old (inclusive) - Men weighing at least 50 kg (about 110 lbs) and women weighing at least 45 kg (about 99 lbs), with a body mass index (BMI) between 18.0 and 30.0 **For Part D (later stu...

Who might be able to join this trial: - People who have been diagnosed with atopic dermatitis (a type of eczema) for at least 1 year before the screening visit, based on American Academy of Dermatology guidelines - People whose eczema severity scores at both the screening and baseline visits are rated at 16 or above on...

Who might be able to join this trial: - People who are willing and able to give their written agreement to take part in the study - People who have been diagnosed with atopic dermatitis (a type of chronic skin condition causing inflammation and itching) for at least 1 year - People whose atopic dermatitis is moderate t...

**Who might be able to join this trial:** - People aged 6 months or older. - People who understand the purpose, methods, and possible risks of the study. - People who can read and understand English. - People who are willing to sign a consent form agreeing to take part. - *[For the patient group only]* People who have...

Who might be able to join this trial: - Your doctor has decided that starting treatment with nemolizumab (Nemluvio®) is right for you, following the approved guidelines for this medicine. - You are aged 12 or older and have been diagnosed with moderate-to-severe atopic dermatitis (eczema). - You (or your legal guardian...

Who might be able to join this trial: - Children of Caucasian ethnicity, of any sex, aged between 6 months and 10 years old, who have a confirmed diagnosis of atopic dermatitis (a type of eczema) - Children of Caucasian ethnicity, of any sex, aged between 6 months and 10 years old, without atopic dermatitis, who are ma...

**Who might be able to join this trial:** - You are 50 years old or older - You are willing and able to have an MRI scan without contrast dye (for example, you do not have a pacemaker, certain types of brain surgery clips, or are not pregnant) **Who may not be able to join:** - You have a history of an autoimmune dise...

**Who might be able to join this trial:** - You must have already completed the full treatment period in a previous APG777 study, and the study doctor must feel you followed the study rules properly - The study doctor must believe that continuing treatment with APG777 for a longer period of time would be beneficial for...

**Who might be able to join this trial:** - You are male or female of any skin tone, and fall into one of these age groups: an infant aged 3 to 23 months, a child aged 2 to 12 years, or a teenager/adult aged 13 or older - You have been diagnosed with atopic dermatitis (eczema) using a specific set of recognised medica...

**Who might be able to join this trial:** - You are between 18 and 65 years old - You weigh at least 40kg (about 88 pounds) - You have been diagnosed with atopic dermatitis (a type of eczema) for at least 12 months before the screening visit, based on recognised medical criteria (previous diagnoses of "dermatitis" or "...

Who might be able to join this trial: - People who are Chinese, male or female, and between 18 and 65 years old (including those aged exactly 18 or 65) - People who are generally in good health, with no other ongoing or treated chronic conditions - People who have previously received treatment for atopic dermatitis (ec...

**Who might be able to join this trial:** - People who have been diagnosed with moderate-to-severe atopic dermatitis (eczema) - People whose eczema did not respond well enough to, or who could not tolerate, at least one topical (applied to the skin) treatment before the screening visit, or for whom topical treatments...

Who might be able to join this trial: - Both the young person and their legal guardian must be willing to follow the study procedures and sign a consent form agreeing to take part. - People aged 12 years old up to (but not including) 18 years old, of any gender, who weigh at least 30 kg at the time of screening and at...

**Who might be able to join this trial:** *If you have asthma or eczema (Study Group):* - You are aged 3 years or older - If you are 18 or older, you can give your own consent to take part; if you are under 18, a parent or guardian can consent on your behalf - You scored positive on a screening questionnaire about ast...

**Who might be able to join this trial:** - People older than 6 months and younger than 65 years of age - People who have been diagnosed with atopic dermatitis (a type of eczema) or contact dermatitis (a skin reaction caused by touching something) - People whose skin condition is considered mild to moderate, based on...

Who might be able to join this trial: - You are between 18 and 75 years old and have been diagnosed with atopic dermatitis (eczema) for at least one year - Your eczema is moderate to severe and has not been well controlled by creams or ointments applied to the skin - You are willing to follow the study's instructions,...

**Who might be able to join this trial:** - People who have been diagnosed with a mild skin barrier condition, such as mild to moderate atopic dermatitis (eczema), mild to moderate chronic plaque psoriasis, contact dermatitis, or dry/flaky skin that occurs seasonally or is visibly noticeable - People whose eczema is c...

**Who might be able to join this trial:** - Adults aged 18 to 75 years (inclusive) with a body mass index (BMI) of 19 or above - People who have been fully informed about the trial and have agreed to take part by signing a consent form - People who have been diagnosed with atopic dermatitis (eczema) by a doctor using...

**Who might be able to join this trial:** - People who have been clinically confirmed to have mild-to-moderate atopic dermatitis (eczema), with a specific disease severity score between 1 and 21 on a standard eczema measurement scale, whose skin clears well with steroid treatment (at least a 90% improvement on that sc...

**Who might be able to join this trial:** - You are willing to sign a consent form, can communicate with the research team, and agree to follow the study rules throughout the trial. - You are between 18 and 75 years old (inclusive) at the time of signing the consent form, and can be male or female. - You have been iden...

**Who might be able to join this trial:** - People who are 18 years of age or older - People who have been diagnosed with atopic dermatitis (a type of eczema) for at least 6 months before the trial starts, with the diagnosis confirmed by photographs - People whose atopic dermatitis is considered moderate to severe, ba...

**Who might be able to join this trial:** - People who are able and willing to follow all parts of the study, including completing skin and quality-of-life questionnaires and providing blood samples throughout the study period - People who were already taking part in a related study called CS45570, were still being ass...

Who might be able to join this trial: - You are able to understand what the study involves and are willing to sign a consent form agreeing to take part. - You have already completed a specific visit (either the Week 18 check-up or the final visit) in one of two related previous studies (called CM512-101102 or CM512-100...

**Who might be able to join this trial:** - You are generally in good health based on a physical exam, medical history, vital signs, and a heart tracing (ECG) done at the screening visit - You have been diagnosed with chronic atopic dermatitis (eczema) for at least 1 year before the screening visit, following recognis...

**Who might be able to join this trial:** **Part A (Healthy Volunteers):** - People who are healthy male or female volunteers between 18 and 65 years old - People whose body weight falls within a moderate range (BMI of 18.5 to less than 32.5) - Women who could become pregnant must have a negative pregnancy test **Par...

**Who might be able to join this trial:** **For all participants (Part A and Part B):** - People aged between 18 and 65 years old - People with a body mass index (a measure of body weight relative to height) between 18 and 28, and who weigh no more than 120 kg - Women who could become pregnant must have a negative pre...

**Who might be able to join this trial:** - Children who are between 2 and 12 years old - Children who have been diagnosed with atopic dermatitis (eczema) based on a specific set of medical criteria called the Hanifin and Rajka criteria - Children whose eczema is classified as mild, based on a scoring system called SCO...

**Who might be able to join this trial:** - People aged 12 years or older - People who are able to understand the study and give their agreement to take part (or have a parent/guardian do so on their behalf) - People who have a confirmed genetic change in the STAT3 gene that causes a condition called Hyper-IgE syndrom...

**Who might be able to join this trial:** - Your baby or toddler was born at full term (at or after 37 weeks of pregnancy) and is between 3 months and under 24 months old at the screening visit - Your child has been diagnosed with atopic dermatitis (eczema) that covers more than 5% of their body, with a confirmed sever...

Who might be able to join this trial: - People who are 18 years of age or older at the time of signing the consent form - People who have been diagnosed with chronic atopic dermatitis (a long-term skin condition with inflammation and itching) for at least 1 year before joining the study - People whose atopic dermatitis...

**Who might be able to join this trial:** - You are 12 years old or older at the time of giving consent to participate. - You have been diagnosed with atopic dermatitis (eczema) of any severity, confirmed by a doctor using standard medical guidelines. - You have been prescribed and are about to start a systemic (whole-...

**Who might be able to join this trial:** - People aged 12 or older who have atopic dermatitis (a type of eczema) that requires whole-body (systemic) treatment, not just creams or ointments - People who have not used any whole-body (systemic) treatment for their eczema in the last 2 months, or who have never used that...

**Who might be able to join this trial:** - People who have been diagnosed with chronic atopic dermatitis (a long-term skin condition also known as eczema) for at least 12 months before the first study visit - People whose atopic dermatitis is rated as moderate or severe at the screening and baseline appointments, bas...

Who might be able to join this trial: - You are between 12 and 17 years old and weigh at least 30 kg (about 66 pounds) at the time of your first screening appointment - You have been diagnosed with atopic dermatitis (eczema) for at least 6 months, based on standard medical guidelines - Your eczema is considered moderat...

**Who might be able to join this trial:** - Your baby is planned to be born at the maternity ward of UZ Brussel hospital - Your baby is considered higher risk for developing eczema (atopic dermatitis) — meaning at least one parent or sibling has been diagnosed by a doctor with eczema, asthma, or hay fever (allergic rhi...

**Who might be able to join this trial:** - You are able to understand and agree to the study terms by signing a consent form - You are 18 years old or older, of any gender - You have been diagnosed with atopic dermatitis (eczema) for at least 1 year, using recognised medical criteria - Your eczema is currently moderat...

**Who might be able to join this trial:** - The baby must be between 0 and 3 months old at the time of joining the study. - The baby must have been born by Cesarean section (C-section), whether it was planned or an emergency. - The baby must have been born at 36 weeks of pregnancy or later (not very early preterm). - T...

Who might be able to join this trial: - Women between the ages of 40 and 60 years old - People who have a non-infectious, non-autoimmune inflammatory skin condition on the face (such as rosacea, acne, or eczema), either self-reported or diagnosed by a doctor - People who are willing and able to drink a small daily drin...

**Who might be able to join this trial:** - The baby was born at the UZ Brussel maternity ward at 37 weeks of pregnancy or later - The baby is in good health at the time of the initial check-up before the study begins - The baby is between 1 and 14 days old at the time of joining the study - The parent(s) or legal gua...

**Who might be able to join this trial:** - You are between 18 and 80 years old - You are male or female and are considered to be in good general health based on your medical history - You have visible eczema on your skin that has been assessed as moderate to severe using standard eczema measurement tools - You are abl...

**Who might be able to join this trial:** - People who are able to understand and sign a consent form agreeing to take part - Healthy men and women aged 18 to 55 years old (inclusive) at the screening visit, with suitable veins for blood draws or needle insertion - People whose body weight and body mass index (a measu...

Who might be able to join this trial: - People who are able to understand the study and are willing to sign a consent form before any study procedures take place, and who are willing to follow all study requirements. - People aged between 18 and 75 years old (inclusive). - People who weigh at least 40 kg and have a Bod...

**Who might be able to join this trial:** - You have no significant health problems found during a physical check-up, heart tracing (ECG), chest X-ray, or blood/urine tests before the study begins. - Your body mass index (BMI) is between 19 and 26, and you weigh between 55 and 85 kilograms (roughly 121 to 187 pounds)....

**Who might be able to join this trial:** - Adults aged 18 or older (as allowed by local rules) at the time of the screening visit - People who have been diagnosed with atopic dermatitis (eczema), with symptoms that started at least 1 year before the screening visit - People whose atopic dermatitis is considered modera...

Who might be able to join this trial: - The child's parents or guardians speak Russian, have been told about the study, understand what it involves, know their rights, and have signed a consent form. - The child has diarrhea or constipation along with colic and/or spitting up (reflux). - The child has skin reactions re...

**Who might be able to join this trial:** - You must be able to understand the study information, communicate with the research team, and sign a written consent form before taking part. - You must be at least 18 years old when you join the study. - You must be someone for whom a doctor has already decided — independent...

**Who might be able to join this trial:** - People who are willing to follow the study procedures, attend required follow-up appointments, and sign a consent form agreeing to take part - People who are able to complete study questionnaires on their own or with help from a caregiver or support person - People who are b...

**Who might be able to join this trial:** - People who are willing and able to sign a written consent form agreeing to take part. - Adults aged 18 to 65 years old at the time of signing consent. - People who are generally healthy, with no significant health problems found during initial medical checks, physical examin...

**Who might be able to join this trial:** - You are a man or woman living in Malaysia and are generally in good health - You are 18 years of age or older - You have been diagnosed by a doctor with eczema that is considered mild to moderate in severity (based on a standard eczema scoring system called EASI, with a score...

Who might be able to join this trial: - People who have moderate to severe atopic dermatitis (a type of chronic skin condition) along with signs of anxiety and/or depression. - People whose doctor has decided to start them on a medication called dupilumab within 30 days of joining the study, as a treatment decision mad...

Who might be able to join this trial: **For the healthy volunteer part of the trial (Phase Ia):** - People who are able to understand the study requirements and are willing to sign a consent form agreeing to take part. - People aged 18 to 55 years (any gender). - Men who weigh at least 50 kg and women who weigh at lea...

**Who might be able to join this trial:** - You are 18 years old or older - A doctor has examined your ear and confirmed you have a specific type of ear inflammation called eczematous otitis externa (a skin condition affecting the ear canal) - You are experiencing at least one of the following in the affected ear: itch...

**Who might be able to join this trial:** **Part A (Healthy Volunteers):** - You are considered to be in good general health, based on your medical history, physical check-up, and test results at the start of the study - Your Body Mass Index (BMI — a measure of body weight relative to height) is between 18 and 31 at t...

Who might be able to join this trial: - People who are 18 years of age or older, of any gender. - People for whom a doctor has already decided, separately from and before this study, to prescribe Stapokibart Injection for atopic dermatitis (a type of eczema), based on the prescribing guidelines used in China. Who may...

**Who might be able to join this trial:** *For Parts 1 & 2 (Healthy Volunteers):* - You are a man or woman aged 18 to 65 years old, in general good health, with a body weight in the normal to slightly overweight range (BMI between 18 and 32) - Women must either not be able to get pregnant, or must not be sexually acti...

Who might be able to join this trial: - You are 18 years old or older - You have moderate-to-severe eczema (atopic dermatitis) that your doctor believes needs to be treated with a medicine called tralokinumab - You are covered by a social security or health insurance scheme - You are able to understand and agree to tak...

Who might be able to join this trial: - Adults aged 18 years or older - People who have a confirmed diagnosis of Atopic Dermatitis (a chronic skin condition that causes itchy, inflamed skin) Who may not be able to join: - People who have used certain whole-body medicines that suppress the immune system, steroid medici...

Who might be able to join this trial: - People who fully understand the study, are willing to follow the trial procedures, and agree to sign a consent form - People who are 12 years of age or older, of any gender, at the time of signing the consent form - People who have been diagnosed with atopic dermatitis (eczema) a...

**Who might be able to join this trial:** - People who fully understand the study, are willing to follow all trial procedures, and agree to sign a consent form - People who are 18 years of age or older (any gender) - People who have been diagnosed with atopic dermatitis (eczema) using a standard set of medical criteria...

**Who might be able to join this trial:** - People aged 18 to 65 years old at the time of signing the consent form - People who have had atopic dermatitis (eczema) for at least 1 year, confirmed by a doctor using recognised diagnostic guidelines - People whose eczema is rated as moderate or severe by the examining doc...

Who might be able to join this trial: **Part 1 – Healthy participants:** - Men and women aged 18 to 55 who are in good general health and have no childbearing potential **Part 2 – Participants with atopic dermatitis (eczema):** - Men and women aged 18 or older who are not pregnant - People who have had a diagnosis of...

**Who might be able to join this trial:** - Adults aged 18 to 75 years at the time of signing the consent form, of any gender - People who have been diagnosed with atopic dermatitis (eczema) according to recognised medical criteria, with a history of the condition for at least 6 months before the screening visit, and...

Who might be able to join this trial: - People aged 12 to 89 years old. - People who have been diagnosed with atopic dermatitis (eczema). - People who have had at least one eczema flare-up in the past 2 months. - People who are willing and able to use a home monitoring device called Nevisense Go, fill in a daily sympto...

Who might be able to join this trial: - A signed general consent form (or similar document) has been completed. - A confirmed diagnosis of Atopic Dermatitis (a chronic skin condition that causes itching and inflammation) has been established. Who may not be able to join: - People who are unable to provide informed con...

**Who might be able to join this trial:** - People aged 12 or older on the day they sign the consent form, and who weigh at least 40 kg before the study begins - People who have had atopic dermatitis (a type of chronic skin condition causing redness, itching, and inflammation) for at least 12 months before their scree...

Who might be able to join this trial: - People who are able to understand what the trial involves and sign a consent form. - People aged 18 to 45 years old at the time of signing the consent form. - Men who weigh at least 50 kg and women who weigh at least 45 kg, with a body mass index (BMI) between 18 and 28. - People...

**Who might be able to join this trial:** - People aged 12 years or older on the day they sign the consent form, and who weigh at least 40 kg before the study begins - People who have had atopic dermatitis (a type of chronic skin condition causing redness, itching, and rashes) for at least 12 months before the screeni...