Phase 3 Ovarian Cancer Trial, Completed

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You have recently been diagnosed for the first time with ovarian cancer, fallopian tube cancer, or primary peritoneal cancer, confirmed by a tissue sample (biopsy)
• Your cancer is at an advanced stage (classified as stage IIB through IV)
• You are female and aged 18 or older
• Your doctors expect you to live for at least 6 months
• You are reasonably active and able to care for yourself, or only need occasional help with daily activities (confirm with trial site)
• You have already had surgery — either an operation to remove as much cancer as possible, or a biopsy/limited surgery if full removal was not possible for stage IV disease
• You are willing and able to sign a written consent form agreeing to take part
• Your first dose of chemotherapy is planned after your wound has healed, but no more than 10 weeks after your surgery

Who may not be able to join:

• Your tumour is non-cancerous, borderline, or a type of cancer that did not start in the lining of the ovary, fallopian tube, or peritoneum
• You have any surgery planned within about 2.5 years of joining the trial, including a delayed tumour-removal operation
• You have a wound, ulcer, or bone fracture that is not healing properly
• You have symptoms of a blocked bowel and need nutrition or fluids given directly into a vein
• Your cancer has spread to the brain
• You already have significant nerve damage causing numbness, tingling, or weakness, unless it was caused by a physical injury
• You have had a serious blood clot in the past (such as a deep vein thrombosis or pulmonary embolism)
• You have a known bleeding disorder, whether inherited or developed over time
• You have significant heart or blood vessel disease
• You have a clinically significant build-up of fluid around your heart
• You have had a stroke, mini-stroke, or bleeding in the brain within the past 6 months
• Your blood test results do not meet the minimum safety levels required for the trial (confirm with trial site)
• You have a serious active infection, or infections such as Hepatitis B, Hepatitis C, or HIV
• You have poorly controlled diabetes or another condition that would make high-dose steroid treatment unsafe
• You have a stomach or bowel condition that would affect how your body absorbs the study medication
• You have been diagnosed with another cancer in the past 5 years (some exceptions may apply for certain treated skin cancers, early cervical cancer, early breast cancer, or low-risk womb cancer — confirm with trial site)
• You have previously had any treatment for ovarian cancer, such as chemotherapy, antibody therapy, targeted therapy, or hormone therapy
• You have previously had chemotherapy for any reason
• You have previously been treated with BIBF 1120 or any other drug that works by blocking the growth of blood vessels in tumours
• You have previously had radiotherapy
• You have a serious illness or condition — physical, neurological, or psychiatric — that could make participation risky
• You are able to have children, are sexually active, and are not using a highly effective form of contraception during the trial and for at least 12 months after treatment ends
• You are pregnant or breastfeeding
• Personal, family, social, or location-related factors that might make it hard for you to follow the trial schedule (confirm with trial site)
• You currently have an active problem with alcohol or drug misuse
• You are unable to follow the requirements of the trial
• You have any medical reason that means you cannot safely receive the chemotherapy drugs paclitaxel or carboplatin
• You have taken part in another clinical drug trial or received an experimental treatment within the past 4 weeks, or are currently in another drug trial

Important: Always verify eligibility with the trial site directly before applying.