Oesophageal Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People diagnosed with a confirmed squamous cell or adenocarcinoma (specific types of cancer) of the esophagus (food pipe), affecting the middle, lower, or junction area where the esophagus meets the stomach, with possible stomach involvement of up to 5 cm.
• People whose cancer has been confirmed through an endoscopy (camera examination of the food pipe) with a tissue biopsy.
• People whose cancer is at a specific stage (T1N1-2, or T2-3N0-2) based on standard cancer staging guidelines, confirmed through a series of required tests including CT scan, PET scan, and ultrasound examination of the food pipe, all completed within required timeframes before joining.
• People who have had a recent physical examination with their weight recorded within 30 days of registering for the trial.
• People whose kidney function blood test results are within an acceptable range within 4 weeks of registration.
• People whose recent blood tests show the bone marrow is producing enough blood cells (sufficient white blood cells, platelets, and haemoglobin levels).
• People whose liver function blood test results are within an acceptable range within 4 weeks of registration.
• People aged 18 or older.
• People with a general health and activity level rated as acceptable on a standard medical scale (Zubrod performance status 0–2) within 4 weeks of registration.
• People who have been assessed by a surgeon and confirmed as able to undergo surgery to remove the cancer after completing pre-surgery treatment.
• Women who could potentially become pregnant must have a negative pregnancy blood test within 14 days before registration.
• Women who could potentially become pregnant, and male participants, must use adequate contraception throughout the trial.
• People who have read and signed the trial's informed consent form before entering the study.

Who may not be able to join:

• People whose esophageal cancer is located in the upper (cervical) part of the food pipe, closest to the throat.
• People whose cancer is at the very earliest stage (T1N0) or the most advanced local stage (T4).
• People who have previously received radiation therapy to the chest or as treatment for esophageal cancer.
• People who have previously received chemotherapy for esophageal cancer.
• People who have a connection or opening between the food pipe and the airway (tracheoesophageal fistula), or whose cancer has grown into the airway or major breathing tubes.
• People who have had another type of invasive cancer in the past, unless they have been free of that cancer for at least 2 years (certain very early-stage cancers such as carcinoma in situ of the breast, mouth, or cervix may still be eligible — confirm with trial site).
• People who have had prior radiation therapy in an area that would overlap with the radiation fields planned for this trial.
• People who have medical reasons that would prevent them from safely undergoing surgery to remove the esophagus.
• People who have previously had an allergic reaction to the chemotherapy drugs paclitaxel or carboplatin.
• People with serious, active other health conditions that may affect survival.
• Women who are pregnant, breastfeeding, or who could potentially become pregnant, and men who are sexually active and unable or unwilling to use medically acceptable contraception.

Important: Always verify eligibility with the trial site directly before applying.