Phase 2 Pulmonary Hypertension Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You have been diagnosed with a specific type of pulmonary hypertension (high blood pressure in the lungs) called WHO Group 1, confirmed by a heart catheter test showing specific pressure and resistance measurements in your lungs
• You are either not taking any medication for your pulmonary hypertension, or your treatment has been stable (no new drugs, no dose changes) for at least the past 4 weeks with no change in your symptoms during that time
• Women who can become pregnant must agree to use reliable birth control (such as hormonal methods, barrier methods, or abstinence) for the entire time they are in the study

Who may not be able to join:

• You have severe right-sided heart failure with the worst level of symptoms (WHO/NYHA Class IV), along with scan evidence of severely poor heart function and physical signs such as swollen legs, fluid in the abdomen, or visible neck vein swelling
• You have pulmonary hypertension caused by, or alongside, liver scarring (cirrhosis) with high liver blood pressure, shown by a history of fluid in the abdomen, mental confusion from liver disease, or enlarged blood vessels in the food pipe
• You currently have an active infection (HIV patients with two recent low viral load results within the past 12 months may still be eligible — confirm with trial site)
• You have taken the medications spironolactone or eplerenone in the past 30 days
• You have a known or suspected allergy to spironolactone
• You are pregnant or currently breastfeeding (all women who could become pregnant will need a pregnancy test before joining)
• You are under 18 years old
• You are unable to give written consent to take part in the study
• You have chronic kidney disease with significantly reduced kidney function (below a certain level measured by a kidney function calculation — confirm with trial site)
• Your blood potassium level is too high at the time of enrollment (above a certain threshold — confirm with trial site)
• You are currently taking both an ACE inhibitor and an angiotensin receptor blocker (two types of blood pressure medicines) at the same time, OR you are already on the highest recommended dose of either one of these medicines
• You are a woman currently taking a contraceptive pill that contains a ingredient called drospirenone

For the MRI scan part of the trial, you may not be able to take part if:

• You have an implanted pacemaker, defibrillator, cochlear implant, nerve stimulator, or any other implanted device that is not safe for MRI
• You have metal fragments in your eyes, embedded shrapnel, or aneurysm clips in your brain
• Your doctor feels you are not well enough to tolerate an MRI scan
• You need sedation to have an MRI
• You are unable to enter or lie still in an MRI scanner due to severe obesity, claustrophobia, severe back pain, or a movement disorder

For the part of the MRI using a contrast dye (gadolinium):

• You have had a severe allergic reaction to gadolinium contrast dye in the past, even after being given preventative medicines
• Your kidney function is below a certain level (a stricter limit than the general kidney exclusion above — confirm with trial site)

Important: Always verify eligibility with the trial site directly before applying.