Asthma Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are between 18 and 60 years old (male or female)
• You have moderate-to-severe allergic asthma, with symptoms such as wheezing, chest tightness, shortness of breath, cough, or nighttime symptoms in the past year
• You have had a breathing test (called a methacholine challenge or a bronchodilator test) that confirms your asthma diagnosis — recent test results may be used instead of doing a new one
• You live permanently within 50 miles of the study clinic
• You are able to show a valid government-issued photo ID to enter the research campus
• You are able to receive asthma medications by mail
• You are willing to follow instructions about medications, diet, and lifestyle as required by the study
• You have access to a vacuum cleaner with a detachable hose
• If you are pregnant or breastfeeding at the start of the study, you may still be able to participate in some parts, but not all procedures (confirm with trial site)
• For the bronchoscopy visit specifically: you are able to go without food or drink for 6 hours beforehand (a small amount of water to take approved medications is allowed)

Who may not be able to join:

• You currently smoke, have been significantly exposed to secondhand smoke (measured by a urine test at screening), or have smoked more than the equivalent of one pack a day for 5 years — this includes e-cigarettes and all inhaled products
• A breath test (called a Smokealyzer) shows a reading above 11 ppm (a measure of smoking exposure)
• You have been diagnosed with certain other lung or heart conditions, including COPD, cystic fibrosis, emphysema, a specific type of lung scarring or damage, sarcoidosis, unstable chest pain (angina), or high blood pressure in the lungs
• You have a known allergy or have had a bad reaction to methacholine (a substance used in a breathing test)
• You have a serious illness that affects your overall health or life expectancy, such as dangerous blood clots, severe heart failure, or an active cancer being treated
• The study doctor believes that taking part would put you at unnecessary risk (confirm with trial site)

Additional reasons you may not be able to take part in the bronchoscopy procedure specifically:

• You are pregnant (confirmed by a urine pregnancy test, if applicable)
• You have a bleeding disorder
• You have significant changes to your face structure or have had major facial surgery
• You have had an asthma flare-up or breathing infection within the 4 weeks before the visit
• Your asthma is classified as "severe persistent" by medical guidelines
• You have a known allergy or have had a bad reaction to lidocaine (a numbing medicine)
• On the day of the visit, your temperature, blood pressure, or heart rate is outside of the safe ranges specified by the study
• You weigh less than 50 kg (about 110 lbs)
• Certain blood test results fall outside safe ranges, including low platelet count, low white blood cell count, low red blood cell levels, abnormal clotting results, or raised kidney markers (confirm specific values with trial site)
• You are having active breathing difficulties (bronchospasm) on the day of the bronchoscopy

Important: Always verify eligibility with the trial site directly before applying.