Early Phase 1 Prostate Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have been diagnosed with prostate cancer (a type called adenocarcinoma) confirmed by a tissue sample (biopsy), which may have been done at another hospital as long as detailed results are available.
• For Group A only: People who are scheduled to have their prostate surgically removed at UCSF within 12 weeks of the study's MRI scans.
• For Group B only: People who have already completed a targeted prostate treatment called HIFU within the past 18 months, and who are scheduled for a guided biopsy at UCSF within 12 weeks of the study's MRI scans.
• People who are willing and able to follow study procedures and sign a consent form.
• People who are generally fit and able to carry out everyday activities with little or no limitation (this is measured by a standard medical scoring system called ECOG, score of 0 or 1).

Who may not be able to join:

• People under 18 years of age, or those whose general health, mental health, or physical condition means they cannot meaningfully agree to take part in the study.
• People who are unable to have an MRI scan, including those with certain medical devices such as a pacemaker or certain types of brain clips that are not safe in MRI machines.
• People who cannot tolerate or have medical reasons to avoid a special internal imaging device used during the MRI scan (called an endorectal coil), such as those who have had certain bowel surgery or who have a latex allergy — though the trial's lead doctor may waive this requirement in some cases.
• People who cannot receive the contrast dye used during MRI (called gadolinium), for example those with a documented allergy to it or those with poor kidney function.
• People who have a metal hip implant or any other metal implant or device that could interfere with MRI scan quality.
• People who have previously had surgery, freezing treatment (cryosurgery), or radiation therapy for prostate or pelvic cancer before joining the study — though for Group B, prior HIFU treatment is allowed; prior prostate scraping surgery (TURP) is not allowed for either group.
• People who are currently using or have previously used hormone-blocking therapy (androgen deprivation therapy); use of a specific type of prostate medication called a 5-alpha reductase inhibitor may be allowed, provided it was stopped at least one month before joining (Group A) or at least 14 days before the MRI scans (Group B).
• People with poorly controlled high blood pressure (above 160/100 at the time of joining), though adjusting blood pressure medications to bring it under control may allow eligibility to be re-assessed.
• People with significant heart failure, classified at a moderate or severe level by a standard medical scale.
• People with a significant history of abnormal heart electrical readings (ECG), a family history of a specific heart rhythm condition (long QT syndrome), or those who have had a heart attack within the past 6 months — though people with a controlled irregular heart rhythm (atrial fibrillation or flutter) may still be considered.

Important: Always verify eligibility with the trial site directly before applying.