Phase 2 Prostate Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are male and have been diagnosed with prostate cancer (specifically a type called adenocarcinoma, confirmed by a tissue test)
• Your cancer has a specific type of DNA repair fault called a "homologous recombination defect" (HRD), confirmed by a validated genetic test on tumour or blood samples
• You are 18 years of age or older
• You are generally well enough to carry out daily activities with little or no limitation (confirm with trial site)
• Your PSA (a prostate cancer marker in your blood) has been rising on at least two tests taken at least one week apart, and is at least 2 on the scale used, despite having very low testosterone levels
• Your testosterone level is very low (due to hormone treatment or surgical removal of the testicles at least one year ago)
• At least 4 weeks have passed since your last cancer treatment, radiotherapy, or surgery (not counting hormone injections)
• Your blood counts (platelets, white blood cells, and haemoglobin) are at healthy enough levels
• Your liver is working well enough, based on blood tests
• Your kidneys are working well enough, based on blood tests
• Your heart has been assessed by a heart specialist and is working well enough
• You have a stored tissue sample available, or you are willing to have a new biopsy taken
• You are willing and able to follow all the requirements of the study
• You have read and signed a consent form agreeing to take part

Who may not be able to join:

• You have a medical reason that prevents you from taking the trial medication
• You have pain from prostate cancer that requires strong (opioid) painkillers
• Your cancer has spread to areas where a temporary increase in tumour activity (which the treatment may cause) could be dangerous — for example, bone spread that risks fracture, or cancer pressing on the spine or blocking the urinary system (confirm with trial site)
• You have previously been treated with platinum-based chemotherapy or a type of drug called a PARP inhibitor (though a small group of up to 8 people with prior use of these treatments may still be considered)
• Your life expectancy is estimated to be less than 3 months
• Your cancer has spread to the brain or the lining around the brain and spinal cord
• You have had a blood clot in the past and are not currently taking blood-thinning medication
• You have had a heart attack or serious chest pain (unstable angina) within the last 2 years
• Your red blood cell concentration is too high, or you have untreated severe sleep apnoea, or your heart failure is not well controlled
• You have had another cancer within the last 5 years (some exceptions apply, such as certain skin cancers or non-invasive cancers that were fully treated, or if you have been completely cancer-free for at least 5 years)
• You have another serious illness, including a severe infection, that could make it unsafe to take part
• There are personal, family, social, or location-related factors that might prevent you from following the study schedule — including alcohol or drug dependency

Important: Always verify eligibility with the trial site directly before applying.