Prostate Cancer Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• Men of any ethnicity who have a close family history of prostate cancer — for example, a father, brother, or son diagnosed with prostate cancer before age 70; or two relatives on the same side of the family with prostate cancer where at least one was diagnosed before age 70; or three relatives on the same side of the family with prostate cancer at any age (where the second-degree relative connection counts only if it is through a female family member).
• Men of Black African or Black African-Caribbean ancestry, where both parents and all four grandparents are of Black African or Black African-Caribbean background.
• Men of any ethnicity who are known to carry a gene change (such as BRCA1, BRCA2, ATM, PALB2, MLH1, MSH2, MSH6, CHEK2, or other DNA repair gene changes listed in the study) that raises the risk of prostate cancer, and/or who have been identified as having a high genetic risk score placing them in the top 10% of risk before joining.
• Men aged between 40 and 69 years.
• Men who are generally well enough to carry out everyday activities, or whose health limits them only to some degree (confirm with trial site what this means for a specific situation).
• Men who do not have any personal, family, mental health, or location-related circumstances that would make it difficult to follow the study's schedule and requirements.

Who may not be able to join:

• Men who have previously had a cancer that is expected to reduce life expectancy to less than five years.
• Men who have already been diagnosed with prostate cancer.
• Men who had a prostate biopsy with a negative (no cancer found) result within the year before joining the trial.
• Men whose other health conditions make a prostate biopsy too risky — for example, those taking blood-thinning or anti-clotting medications such as Warfarin, Clopidogrel, Apixaban, Dabigatran, or similar medicines; those with poorly controlled diabetes; those with significant heart or lung conditions; those taking medications that suppress the immune system; or those who have had their spleen removed.
• Men with a body mass index (BMI) of 40 or above.
• Men with a BMI of 35 or above who also have other significant health conditions.
• Men who cannot safely have an MRI scan — for example, those with certain pacemakers, aneurysm clips, metal heart valves or stents, certain brain implants, cochlear implants, nerve stimulators, metal fragments in the eyes, or other metalwork in the body, or those with severe claustrophobia (fear of enclosed spaces).
• Men with significant mental health conditions that may be made worse by taking part in the study.

Important: Always verify eligibility with the trial site directly before applying.