Phase 2 Vasculitis Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have a specific type of enlarged, widened artery (called a dolichoectatic aneurysm) in the back part of the brain that cannot be treated with surgery or other standard procedures.
• People who are older than 18 years of age at the time the study treatment begins.

Who may not be able to join:

• People who have taken certain immune-system-suppressing medications (such as abatacept, rituximab, tocilizumab, or similar "biologic" drugs) in the past 12 months.
• People whose blood test results at the screening visit show too few white blood cells, too few platelets, low red blood cell levels, liver enzyme levels that are three or more times higher than normal, or poor kidney function.
• People who test positive for tuberculosis (TB) exposure on a skin or blood test, unless there is documented proof that a full course of treatment or prevention treatment has been completed or is ongoing for at least 30 days. People with active TB infection are also excluded.
• People who have a past history of a positive TB test or a chest X-ray suggesting prior TB, without records showing that TB treatment or preventive treatment was carried out.
• People who currently have open sores or ulcers on their legs.
• People who have a long-term or persistent infection, including HIV, untreated hepatitis B, listeria, TB, or other serious infections. (People with hepatitis C without serious liver damage, or those with chronic hepatitis B who are on antiviral treatment, may be considered on a case-by-case basis — confirm with the trial site.)
• People who have had a serious active infection requiring hospital care or intravenous antibiotics, antivirals, or antifungal treatment in the 30 days before joining the trial, or who have taken oral antibiotics, antivirals, or antifungals in the 14 days before joining.
• People who have received a live vaccine within 4 weeks before joining the trial.
• People who have had a cancer diagnosis in the past 5 years, except for certain early-stage, localised skin cancers or cervical carcinoma in situ that have been fully treated.
• People who, in the trial doctor's judgment, would face unacceptable risk by taking part in the study.
• Women who are able to become pregnant, are sexually active, and do not agree to use an accepted form of contraception throughout the study (such as condoms, diaphragm, intrauterine device, oral or injected contraceptives started at least 2 months before the study drug, a vasectomised partner, or abstinence).
• Women who are pregnant (a negative pregnancy blood test is required for all women who could potentially become pregnant) or who are currently breastfeeding.
• People who have taken any other experimental drug or treatment within 4 weeks, or within 5 half-lives of that drug (whichever is earlier), before joining the trial.
• People who have had a problem with drug or alcohol misuse in the 6 months before joining the trial.
• People who have a known allergy or sensitivity to any of the study medications or products.
• People who have a psychiatric condition that prevents them from being able to give informed consent to participate.
• People who are unwilling or unable to follow the study requirements.
• People who are unable to have an MRI scan.

Important: Always verify eligibility with the trial site directly before applying.