Phase 4 Peripheral Arterial Disease Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have a long-term history of claudication (leg pain or cramping during walking caused by reduced blood flow).
• People whose leg pain during walking has been confirmed by a vascular surgeon, both through discussion and by observing them during a walking test.
• People who have been found to have reduced blood flow in the arteries of their legs, confirmed through blood pressure measurements at the ankle compared to the arm, and/or other imaging tests.
• People who have had a stable, unchanged treatment routine for blood pressure, cholesterol, and diabetes (if applicable) for at least 6 weeks.

Who may not be able to join:

• People who have leg pain at rest or open sores or tissue damage on their legs caused by poor blood flow (sometimes called Fontaine stage III or IV disease).
• People who have recently had a sudden loss of blood flow to a leg caused by a blood clot or a physical injury.
• People whose ability to walk is significantly limited by conditions other than leg artery disease, such as joint or muscle problems, nerve problems, or heart or lung conditions.
• People who are currently taking a type of blood pressure medication called an ACE inhibitor or an angiotensin II receptor blocker.
• People who have chronic kidney disease with significantly reduced kidney function (a specific kidney filtration measurement below 30 ml/min/1.73m² — confirm with trial site if unsure how this applies).
• People who have a history of severe narrowing of the arteries supplying both kidneys.
• People who have previously had a serious allergic reaction called angioedema related to an ACE inhibitor medication, or who have a known allergy or sensitivity to ramipril or similar medications.

Important: Always verify eligibility with the trial site directly before applying.