Schizophrenia Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People aged between 18 and 50 years, of any gender.
• People who are able to give written informed consent.
• People who have been diagnosed with a schizophrenia-spectrum disorder and who score above 10 on a consent-related assessment called the Evaluation to Sign Consent (ESC).
• People who are currently receiving care from a licensed primary care or mental health provider, such as a psychiatrist, psychologist, nurse practitioner, or licensed clinical social worker.
• People who continue to hear voices (auditory hallucinations) despite having been treated with two or more antipsychotic medications, including at least one newer (atypical) antipsychotic.
• People who agree to allow the research team to communicate with their current and recent healthcare providers, and who can provide contact details for at least two reliable people aged 22 or older who live within a 30-minute drive of the participant's home and who the research team may contact if needed during the study.

Who may not be able to join:

• People who have a close family member (parent, sibling, or child) with inherited epilepsy or a seizure disorder, or people who answer "yes" to certain questions on an epilepsy screening questionnaire.
• People taking more than 400 mg of clozapine per day who are not also taking a sufficient dose of anti-seizure medication.
• People who do not pass a screening questionnaire related to TMS (a type of brain stimulation treatment used in this trial).
• People who have used alcohol or drugs other than nicotine or marijuana in the past month, or who have a history of substance dependence within the past six months and have used substances within the past month.
• People with serious medical conditions that may affect normal brain function, such as stroke, brain infection, or brain tumour.
• People with certain medical devices in or near their body, such as a cardiac pacemaker, implanted medication pump, intracardiac lines, or metal implants in or near the head (such as aneurysm clips, shunts, brain stimulators, cochlear implants, or electrodes), or who have unstable heart disease.
• People with a history of a head injury that caused loss of consciousness for more than 10 minutes, or who have had brain surgery.
• People who are unable to avoid using alcohol or marijuana for 24 or more hours before study sessions.
• Women who are pregnant, may be pregnant (for example, due to a missed period or recent unprotected sex without birth control in the last 4 weeks), or who test positive on a pregnancy test.
• People assessed as being at moderate-to-high risk of suicide based on a standardised scale (the Columbia Suicide Severity Rating Scale), or in the clinical judgement of the study doctor.
• People with certain conditions or circumstances that a doctor determines may raise the risk of seizures — including but not limited to sleep deprivation, certain nutritional or metabolic problems, use of certain medications, alcohol withdrawal, use of stimulants such as cocaine or MDMA, serious infections, or fever (confirm with trial site).
• People with a personal or family history of deep vein thrombosis (blood clots in the veins).

Important: Always verify eligibility with the trial site directly before applying.