Alzheimer's Disease Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

Group 1 – People with normal cognition:

• People who have no concerns about their own memory or thinking ability
• People who show no signs of cognitive problems on formal testing, as reviewed by an expert panel
• People with a Clinical Dementia Rating (CDR) score of 0 or 0.5 (a standard measure of memory and thinking; confirm with trial site)
• People whose blood sugar response to a sugar-drink test falls within the normal range (below 140 mg/dL at 2 hours), according to standard guidelines
• People who have a trusted family member, friend, or carer available to attend at least the first study visit with them

Group 2 – People with Mild Cognitive Impairment (MCI):

• People who show measurable memory and/or problem-solving difficulties on formal testing
• People with a CDR score of 0 or 0.5
• People who have a trusted family member, friend, or carer who can attend study visits with them

Group 3 – People with Alzheimer's Disease (AD):

• People who have been diagnosed with mild Alzheimer's disease, or a combination of Alzheimer's and blood vessel-related brain changes (without a large stroke), confirmed by an expert panel
• People with a score of 10 or above on a standard memory and thinking test (MMSE), and a CDR score of 0.5 or higher
• People whose blood sugar levels are in the normal range or in the pre-diabetes range
• People who have a trusted family member, friend, or carer available to attend all study visits

Who may not be able to join:

• People with significantly abnormal blood test results
• People with a serious neurological condition affecting thinking (other than Alzheimer's disease), such as stroke, Parkinson's disease, multiple sclerosis, or a severe head injury with more than 30 minutes of unconsciousness in the past year, or lasting brain damage from an injury
• People with a serious medical illness or major organ failure, including severe uncontrolled heart disease, lung disease requiring oxygen, severe liver disease, advanced kidney disease or near-dialysis, active cancer, or any life-limiting condition with a life expectancy of less than 3 years
• People currently misusing substances or alcohol, defined as drinking more than 14 alcoholic drinks per week, or people with a history of alcoholism or substance misuse within the past 10 years
• People with poorly controlled depression or another psychiatric condition, as assessed by the study team
• People currently taking certain medications, including anti-psychotics, benzodiazepines (taken more than 3 times per week), blood thinners (for those having a lumbar puncture), or strongly sedating or anticholinergic medicines
• People taking anti-seizure medication for a diagnosed seizure disorder (use for other conditions will be reviewed individually by the study doctor)
• People currently using insulin
• People who are unable to have a brain MRI scan, including those with pacemakers, aneurysm clips, artificial heart valves, ear implants, or metal objects in the eyes
• People who are unable to lie still in a scanner for 40 minutes, or who experience claustrophobia (for those completing brain imaging)
• People with significant obesity or a lower back condition likely to make spinal fluid collection difficult, as assessed by the study doctor (for a specific sub-study)
• People with other significant medical conditions, at the discretion of the research team

Important: Always verify eligibility with the trial site directly before applying.