Phase 2 Oesophageal Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You have been diagnosed with esophageal or gastric (stomach) cancer of a specific type called adenocarcinoma, confirmed by a biopsy or tissue sample.
• You have had specific scans (including a scope of the digestive tract and a PET/CT scan) to determine the stage of your cancer.
• You have three or fewer areas in your body where the cancer has spread (metastases), either at diagnosis or after an initial round of chemotherapy has reduced the number of spread sites to three or fewer.
• Each type of spread counts separately: spread to lymph nodes in distant areas counts as one site total; spread to bones counts as one site; spread to the brain, each individual spot counts as one site.
• You are physically well enough to carry out basic daily activities (rated on a standard scale from 0–2) and are expected to live at least 6 months or more.
• You are between 18 and 80 years old and are able to give written consent to participate.
• If you are a woman who could become pregnant, you must take a pregnancy test at enrollment and agree to use reliable contraception during the study and for six months after treatment ends.

Who may not be able to join:

• You have already received chemotherapy or radiation therapy for your esophageal or gastric cancer diagnosis.
• You have had previous radiation to the same body area for a different cancer.
• You have an abnormal opening or connection between organs (called a fistula), confirmed by imaging or a scope procedure.
• Your life expectancy is less than 6 months, or your general health and ability to function is severely limited (confirm with trial site).
• You are pregnant, confirmed by a blood test.
• You have a history of uncontrolled chest pain (angina), heart failure, or a heart attack within the last 6 months.
• You are currently breastfeeding.
• You are in a poor nutritional state (confirm with trial site on what this means for you).
• Your bone marrow is not working well enough to produce healthy blood cells.
• You have a serious active infection.
• You have a known allergy or sensitivity to the chemotherapy drug 5-fluorouracil (5-FU).
• You are known or suspected to have a condition called dihydropyrimidine dehydrogenase (DPD) deficiency, which makes it harder for your body to process certain chemotherapy drugs safely (confirm with trial site).

Important: Always verify eligibility with the trial site directly before applying.