Phase 2 Osteoarthritis Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who are able to give informed consent to participate in the study
• People who have had chronic pain lasting more than 3 months
• People whose knee X-ray (taken standing, with knees straight) shows a Grade 2 or 3 level of knee joint changes, based on a standard medical grading system called the Kellgren-Lawrence classification
• People who rate their pain at least 40 out of 100 on a pain scale
• People between 18 and 75 years old
• People who have had a physical exam and provided their medical history
• People whose blood test results — including platelet count and blood cell levels — are within the normal range
• People whose C-Reactive Protein (a blood marker for inflammation) is within the normal range
• People whose Erythrocyte Sedimentation Rate (another blood marker for inflammation) is within the normal range
• People who have provided a list of their current medications

Who may not be able to join:

• People who have a significant knee alignment problem (the knee bends inward or outward by more than 5 degrees)
• People who have had surgery on the knee being treated within the past 12 months
• People who have an autoimmune disorder (a condition where the immune system attacks the body)
• People who have an active infection
• People whose immune system is suppressed (for example, due to AIDS or similar conditions)
• People who are on blood-thinning medication
• People who have used anti-inflammatory pain medicines (such as ibuprofen or naproxen) within 5 days before a blood draw, or within 7 days after the last study treatment
• People whose haemoglobin level is below 12 g/dL (a measure of red blood cells in the blood)
• People whose platelet count is below 150,000 per mm³
• People who have received an injection into the knee joint within the 3 weeks before the planned treatment
• People who are pregnant or breastfeeding
• People who have a known sensitivity or allergic reaction to hyaluronic acid (HA)
• People who are unable to have an MRI scan due to metal implants in their body or due to severe claustrophobia (fear of enclosed spaces)
• People who have diabetes
• People who are currently receiving treatment for cancer
• People who have an open or active wound on the knee
• People who have recently experienced a knee injury (confirm with trial site for specific timeframe)
• People who have a history of fainting or near-fainting (vasovagal episodes)
• People who have received an injection of hyaluronic acid or platelet-rich plasma (PRP) into the affected knee within the past two years
• People who, in the opinion of the trial investigator, would be unable to attend all required visits or complete all required treatments

Important: Always verify eligibility with the trial site directly before applying.