Alzheimer's Disease Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

This trial has several different groups. Depending on your situation, you may qualify under one of the following categories:

General community participants:

• You are aged 55 or older (male or female) and willing to give your consent to take part

Mild Cognitive Impairment (MCI) group:

• You have been diagnosed with MCI (a mild level of memory or thinking difficulties that does not yet meet the level of dementia) based on recognised medical criteria
• Your memory loss is noticeable and may affect other areas of thinking
• Your symptoms came on gradually and have been slowly progressing
• You are willing to have a blood test and sign a consent form

Sporadic Alzheimer's disease group (no family history):

• You have been diagnosed with Alzheimer's disease using recognised medical criteria, with no known family history of dementia
• You and someone close to you are able to take part in follow-up check-ups
• You or your legal guardian are willing to sign a consent form

Familial Alzheimer's disease group (runs in the family):

• You are aged 18 or older and belong to a family where at least two close relatives (such as parents or siblings) have been diagnosed with Alzheimer's disease
• At least two people who know you well are available to provide information about you
• You or your legal guardian are willing to sign a consent form before any study procedures begin

Vascular dementia group:

• You have been diagnosed with vascular dementia (dementia related to problems with blood flow to the brain) based on recognised medical criteria
• Your brain scan (MRI) results match specific patterns related to vascular dementia (confirm with trial site)
• You are willing to have an MRI scan, a blood test, and sign a consent form

Healthy control (comparison) group:

• You are aged 18 or older with no memory or thinking problems
• Your scores on standard memory and thinking tests are within the normal range for your level of education
• You are willing to have a blood test and sign a consent form

Who may not be able to join:

• You have had a stroke or have significant blood vessel disease changes visible on a brain scan
• You have another brain or nervous system condition, such as Parkinson's disease, a brain tumour, epilepsy, multiple sclerosis, depression, brain injury, or a history of encephalitis (brain inflammation)
• You have a serious illness affecting other parts of your body that can affect memory or thinking, such as severe liver, kidney, or thyroid problems, severe anaemia, vitamin B12 or folic acid deficiency, syphilis, HIV, or issues with alcohol or drug use
• You have a history of mental illness or a developmental condition affecting your mental abilities
• You are unable to have an MRI scan for any reason (for example, having a metal implant — confirm with trial site)
• You have a condition that would prevent you from completing memory and thinking tests
• You are not willing to have a blood test
• You are not willing to sign the consent form
• (For the familial Alzheimer's group only) You are pregnant or breastfeeding
• (For the familial Alzheimer's group only) You have a severe psychiatric illness that would make it very difficult to complete the study assessments
• (For the healthy control group only) Your memory and thinking test scores fall outside the normal range
• (For the healthy control group only) You have a history of stroke or brain injury, or your MRI shows related changes

Important: Always verify eligibility with the trial site directly before applying.