Alzheimer's Disease Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

If you come from a family with Alzheimer's disease (Familial AD group):

• You are willing and able to give written agreement to take part (or a legal guardian can do this on your behalf)
• At least two close relatives (like parents or siblings) in your family have been diagnosed with Alzheimer's disease, and at least 3 people across 2 generations in your family have the condition
• At least one person in your family has normal memory and thinking ability, and is older than the average age when Alzheimer's started in your family
• Your family carries a known gene change linked to inherited Alzheimer's disease (in the APP, PSEN1, or PSEN2 genes)
• You are over 18 years old and belong to this family
• Your memory and thinking are either normal or affected by dementia, but you are not completely bedridden
• You can provide two reliable people who know you well and can share information about your health and daily life
• Your memory or thinking problems, if any, have been formally diagnosed using recognised medical guidelines (confirm with trial site)

If you are a healthy volunteer (Normal Control group):

• You are 18 years old or older
• You score within the normal range on standard memory and thinking tests, based on your level of education (confirm with trial site for exact score requirements)

Who may not be able to join:

Familial AD group:

• Your memory or thinking problems are caused by something other than Alzheimer's, such as depression, thyroid problems, a brain injury, brain tumour, or another type of dementia (e.g. vascular dementia or Lewy body dementia)
• Your brain scan (MRI) or blood test results do not clearly support an Alzheimer's diagnosis
• You have a serious ongoing illness affecting your heart, lungs, kidneys, digestive system, blood, or you have cancer (for example, unstable chest pain, uncontrolled asthma, or active stomach bleeding)
• You have a severe mental health condition or are so severely affected by dementia that you cannot take part in assessments
• You have a history of alcohol or drug misuse
• You are pregnant or breastfeeding
• You cannot provide two reliable people who know you well to share information about you
• For spinal fluid collection (lumbar puncture): you have a blood clotting problem, a very low platelet count, had spinal surgery in the last 6 months that affects the spine's structure, or have a history of repeated fluid leaks after previous spinal procedures
• For brain scans (MRI): you have metal implants such as a pacemaker, artificial heart valve, metal joint, or metal in the eye, or have an aneurysm clip in the brain

Normal Control group:

• Your memory and thinking test scores fall outside the normal range
• You have a history of stroke, brain injury, or related findings on a brain scan
• You have a neurological condition that can affect brain function, such as Parkinson's disease, epilepsy, depression, or a brain tumour
• You have another health condition known to affect memory and thinking, such as liver, kidney, or thyroid problems, severe anaemia, vitamin deficiencies, syphilis, HIV, or a history of alcohol or drug misuse
• You have an intellectual or developmental disability
• You have a condition that prevents you from completing memory and thinking assessments (confirm with trial site)
• You have a reason you cannot safely have an MRI scan
• You are unwilling to have a blood test
• You are unwilling to sign the consent form at the start of the study

Important: Always verify eligibility with the trial site directly before applying.