Phase 2 Pancreatitis Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are an adult who came to the Emergency Department or was admitted to hospital through a GP with a new diagnosis of acute pancreatitis (a sudden inflammation of the pancreas), confirmed by at least two of these three things: typical severe upper belly pain, a blood test showing raised pancreatic enzymes (amylase and/or lipase at least 3 times the normal level), or a CT or MRI scan showing signs of pancreatitis
• The trial treatment can be started within 36 hours of you being admitted to hospital with this new diagnosis
• You (or your legal representative, if you are unable to consent yourself) have agreed to take part and given written consent

Who may not be able to join:

• You are under 18 or over 85 years old
• You weigh more than 200 kg
• You have had acute pancreatitis in the last 30 days, or you have long-term (chronic) pancreatitis
• You have multiple sclerosis, systemic vasculitis, Guillain-Barré syndrome, or another condition affecting the nerve coverings (confirm with trial site)
• You have a known history of epilepsy
• You have moderate to severe heart failure or significant coronary (heart) disease
• You have a serious lung condition, including cystic fibrosis, severe asthma, or severe COPD
• You use oxygen at home or a breathing machine at home
• You have yellowing of the skin or eyes (jaundice) or known advanced liver disease
• You have a known cancer for which you are currently receiving, or have recently finished (within the last 6 months), chemotherapy or radiotherapy
• You have a known cancer of the blood or bone marrow
• You have a known cancer that is being managed with palliative (end-of-life) care
• You have a known or suspected active infection, including COVID-19, at the time your pancreatitis began
• You have a known history of tuberculosis (TB), or you live with someone who has TB, or you have had a serious opportunistic infection (an infection that occurs when the immune system is weakened)
• You have a known history of hepatitis caused by infection (infective hepatitis)
• You have a rare disease or inherited condition that significantly raises your risk of infections, such as severe combined immunodeficiency (SCID) or homozygous sickle cell disease
• You have received a live vaccine or been given any infectious agent within the month before being admitted to hospital
• You have taken immunosuppressant or biologic medicines within the month before being admitted to hospital
• You have a known allergy or sensitivity to infliximab, any of its inactive ingredients, or any proteins derived from mice
• You are known to be pregnant or breastfeeding at the time of admission
• You are a woman who could become pregnant and are not willing to use reliable contraception for up to 6 months after receiving the trial treatment
• You have taken part in another clinical drug trial within the last three months

Important: Always verify eligibility with the trial site directly before applying.