Phase 2 Ovarian Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You have a solid tumor cancer that has come back, is getting worse, or has not responded to treatment, and you have already tried or are not able to receive the standard treatments available for your cancer.
• You are generally well enough to carry out everyday activities with little or no limitation (as measured by a standard activity scale called ECOG 0-1).
• You have a specific genetic marker called HLA-A*02:01 (a blood test can check for this).
• If you have ovarian or fallopian tube cancer: your cancer has been confirmed as a specific type (high-grade serous or endometrioid epithelial ovarian cancer, primary peritoneal cancer, or fallopian tube cancer).
• If you have uterine (endometrial) cancer: your diagnosis has been confirmed by a tissue sample showing recurrent or persistent endometrial carcinoma.
• Your cancer can be measured on scans using a standard method called RECIST 1.1.
• Your heart, liver, kidneys, and other organs are working well enough to meet the trial's requirements.
• Your tumor has been tested and shown to carry a specific protein (tumor antigen) detected by a special test called IMADetect® RT-qPCR.
• Your doctors expect you to live for more than 5 months.
• If you are a woman who could become pregnant, you must use reliable contraception before joining the trial and for 12 months after receiving the treatment.
• If you are a man, you must use effective contraception or abstain from sex while on the trial and for 6 months after receiving the treatment.
• Any side effects from previous cancer treatments have mostly or fully gone away (reduced to Grade 1 or lower) before starting this trial's preparation treatment.

Who may not be able to join:

• You have been diagnosed with another cancer in the last 3 years (with the exception of certain treated skin cancers or very early-stage cancers).
• You are currently pregnant or breastfeeding.
• You have a serious autoimmune disease (though the trial doctor may still consider you if your condition is well controlled without immune-suppressing medicines).
• You have a history of certain heart conditions as specified by the trial (confirm with trial site).
• You have previously had a stem cell transplant or an organ transplant.
• You have another serious or uncontrolled medical condition that could make it unsafe to participate.
• You have a condition that affects your immune system, or have had past treatments that significantly weakened your immune system.
• You are HIV positive, or currently have an active hepatitis B or hepatitis C infection.
• A specific blood marker related to cell breakdown (LDH) is more than twice the normal upper limit.
• You have any condition that would make it unsafe to undergo the procedures involved in this trial, including the blood collection process (leukapheresis), the preparation treatment (lymphodepletion), low-dose IL-2, or the trial's main treatment (confirm with trial site).
• You have active cancer that has spread to your brain.
• You are currently taking part in another clinical trial.
• If the trial involves a drug called nivolumab: you have previously had a severe (Grade 3 or 4) reaction to a type of immunotherapy drug known as a PD-1/PD-L1 inhibitor (such as pembrolizumab, atezolizumab, or nivolumab).

Important: Always verify eligibility with the trial site directly before applying.