Stroke Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• Adults aged 18 or older
• People who had a stroke with a certain level of severity (measured by a standard stroke scale), assessed either within 16 hours or between 16 and 24 hours after they were last known to be well
• People whose stroke is caused by a blockage in one of the major blood vessels supplying the front part of the brain
• People whose brain scan results meet specific criteria showing how much of the brain has already been affected (the exact criteria depend on how much time has passed since the stroke)
• People who were living independently or with only minor disability before the stroke (confirm with trial site)
• People considered suitable for a procedure to physically remove the blood clot, where the procedure is expected to begin within 24 hours of last being known well and within 90 minutes of arriving at the emergency department

Who may not be able to join:

• People who were placed on a breathing machine (ventilator) in the emergency department before being assessed by an anaesthetist, or for any reason other than the planned clot-removal procedure
• People whose stroke symptoms improved quickly on their own, suggesting the blockage may have already cleared
• People with a known serious allergy to the contrast dye used in medical imaging
• People currently taking part in another clinical trial involving an investigational drug or medical device
• People with significant kidney problems, as shown by specific blood test results
• People who require kidney dialysis, or who cannot safely undergo a procedure involving dye injected into the blood vessels
• People with a life expectancy of less than 90 days
• People whose symptoms suggest bleeding around the brain (even if scans appear normal at first)
• People with another serious illness or condition that could interfere with assessing how the brain or body recovers, or with completing follow-up visits
• People with a recent history of illicit drug use, or who regularly drink more than 4 alcoholic drinks per day
• People experiencing life-threatening low blood pressure due to severe infection or heart failure
• People whose brain scan shows active bleeding inside the skull
• People whose scan shows a large tumour or significant pressure/swelling in the brain (a very small, non-aggressive tumour type may not automatically exclude someone — confirm with trial site)
• People whose scan shows that more than one-third of a major brain region is already affected by the stroke
• People whose scan shows a large area of brain tissue already severely damaged
• People whose scan shows the stroke is not in the front part of the brain
• People whose imaging suggests, in the medical team's judgement, that the clot-removal procedure would not be appropriate or safe
• People with a personal or family history of a serious reaction to general anaesthesia called malignant hyperthermia
• People with a known allergic or severe reaction to anaesthetic medications
• People who cannot lie flat on their back due to severe heart failure
• People who depend on supplemental oxygen, or have a known lung condition (including pulmonary hypertension) that could make it difficult to come off a breathing machine after the procedure

Important: Always verify eligibility with the trial site directly before applying.