Phase 3 Stroke Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who are showing symptoms of a stroke affecting the back part of the brain (posterior circulation stroke), caused by a partial or complete blockage of a major artery at the base of the brain called the basilar artery.
• Symptoms must have started — or the person must have been last seen well — within the past 24 hours.
• The basilar artery blockage must be confirmed by a CT scan or MRI scan of the blood vessels.
• People aged 18 years or older.
• People who, before this stroke, were either fully independent or needed only minor help at home and could manage on their own for at least one week (a disability score of 3 or less on a standard scale).
• Consent requirements under local laws must have been met.

Who may not be able to join:

• People whose brain scan shows bleeding in the brain or another condition such as a brain tumour.
• People whose brain scan shows a low score on a specific rating system (called pc-ASPECTS) that suggests a large area of the brain has already been seriously damaged (score below 7).
• People showing signs of significant swelling in the cerebellum (back of the brain) or a dangerous build-up of fluid on the brain (acute hydrocephalus).
• People whose CT scan shows a large area of the brain has already died, suggesting the stroke happened some time ago.
• People with extensive damage to both sides of the brainstem.
• People where the treating doctor suspects the blockage is due to longstanding narrowing of the arteries or a tear in an artery wall, which may need a different type of procedure rather than clot-dissolving medication.
• People who, before this stroke, already had moderate to severe disability (a score of 4 or more on a standard disability scale).
• People who have other standard medical reasons why clot-dissolving medication given through a drip would not be safe (confirm with trial site).
• People who cannot have contrast dye used during scans.
• People who are visibly pregnant.
• People who are currently taking part in another research study involving a drug treatment.
• People with a known terminal illness where survival beyond one year would not be expected.
• People for whom a decision has already been made to withdraw active treatment or move to comfort care only.
• People where the treating doctor judges that joining the study could pose a risk to their safety or affect their ability to participate.

Important: Always verify eligibility with the trial site directly before applying.