Phase 2 Stroke Trial, Recruiting
Who may be able to join
AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI
Who might be able to join this trial:
- People who have had an acute ischemic stroke (a stroke caused by a blocked blood vessel) on the left side of the brain
- People who spoke English fluently before their stroke, by their own report
- People who are able to give informed consent themselves, or who have a legally authorised representative who can do so on their behalf
- People who are 18 years of age or older
- People who are within 5 days of when their stroke began
- People who were right-handed before their stroke, by their own report
- People who have been diagnosed with aphasia (difficulty with language and communication after stroke), confirmed by a specific language assessment test called the Western Aphasia Battery-Revised
Who may not be able to join:
- People who have a previous neurological condition affecting the brain, including a previous stroke that caused symptoms
- People who have a diagnosis of schizophrenia, autism, or another psychiatric or neurological condition that affects naming or language
- People who have additional risk factors for a specific heart rhythm problem called torsades de pointes — for example, heart failure, low potassium levels, or a family history of Long QT Syndrome
- People who are currently experiencing severe depression, based on a score above 15 on a standard depression questionnaire (PHQ-9)
- People who have uncorrected vision loss or hearing loss, by their own report
- People who were taking any FDA-approved antidepressant medication at the time their stroke began
- People who are currently taking certain medications, including MAOIs (a type of antidepressant), pimozide, drugs that affect heart rhythm (QT interval), triptans, or other medications that may not be safely combined with the study drug escitalopram (confirm with trial site)
- People whose heart rhythm test (ECG) shows a QTc measurement greater than 450 milliseconds, or whose blood sodium level is below 130 at the start of the study
- People who were pregnant at the time of their stroke, or who are planning to become pregnant during the study period
Important: Always verify eligibility with the trial site directly before applying.
Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.
Contact this trial
Principal Investigator: Argye Hillis-Trupe, MD, Johns Hopkins University
Phone: (410) 614-2381
Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.
GP referral letter
Print a one-page summary to share with your doctor.
Trial details
Where this trial is recruiting
Primary endpoints
Change in Philadelphia Naming Test short-form accuracy score
Can't join this trial?
Data last synced from ClinicalTrials.gov: 20 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.