Breast Cancer Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who are female and between 18 and 75 years old
• People who have been diagnosed with invasive breast cancer, confirmed by a pathology test
• People who have had a mastectomy (full breast removal) and removal of more than 10 lymph nodes from the armpit area — breast reconstruction on the same side, either at the time of surgery or later, is acceptable
• People whose surgery removed all the cancer with clear margins (no cancer cells found at the edges of the removed tissue)
• People whose cancer fits certain staging categories: either a smaller tumour (T1–2) that has spread to 1–3 lymph nodes AND at least one of the following risk factors applies — aged under 40, Grade 3 tumour, cancer found in blood or lymph vessels, hormone receptor negative (ER/PR negative) or HER2 positive; OR a larger tumour (T3–4); OR cancer spread to 4 or more lymph nodes (confirm with trial site)
• People with no signs of cancer spread to distant parts of the body
• People with no cancer spread to the lymph nodes above the collarbone or behind the breastbone
• People with a good general health and activity level (ECOG score of 0 or 1, meaning largely able to carry out daily activities — confirm with trial site)
• People who have received or are receiving standard treatments after surgery, such as chemotherapy, hormone therapy, or HER2-targeted therapy
• People who did not receive chemotherapy before their surgery
• People who are medically suitable to receive radiotherapy after surgery, with no known reasons that would prevent it
• People who have signed a consent form agreeing to take part

Who may not be able to join:

• People who have or have had another cancer, apart from certain common skin cancers (basal cell or squamous cell skin cancer)
• People who have previously had radiotherapy to the chest wall or nearby lymph node areas
• People with serious heart or lung conditions unrelated to cancer
• People with certain medical conditions that make radiotherapy unsafe, such as systemic lupus erythematosus or cirrhosis of the liver
• People whose cancer has spread to 1–3 lymph nodes (T1–2N1) but does not have any of the specific risk factors listed above (under 40, Grade 3, lymphovascular invasion, ER/PR negative, or HER2 positive)
• People with cancer spread to the lymph nodes above the collarbone or behind the breastbone
• People with confirmed evidence that cancer has spread to other parts of the body
• People with cancer in both breasts, or a history of invasive breast cancer in the other breast
• People who received chemotherapy before their surgery
• People with a poor general health and activity level (ECOG score of 3–4, meaning significantly limited in daily activities — confirm with trial site)
• People who are pregnant or breastfeeding
• People whose circumstances or health would make it difficult to complete the radiotherapy treatment or attend follow-up appointments
• People who are unwilling or unable to sign a consent form

Important: Always verify eligibility with the trial site directly before applying.