Breast Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• Women aged 50 or older who have a single breast cancer tumour (in one location only), confirmed by mammogram, ultrasound, and MRI.
• People whose general health and ability to carry out daily activities meets a certain minimum level (confirm with trial site).
• People whose tumour size has been measured using MRI.
• People whose tumour biopsy shows a lower-grade cancer (grade 1 or 2 on a standard pathology scale).
• People whose tumour is not of the lobular invasive type (a specific cancer cell pattern — confirm with trial site if unsure).
• People whose tumour tests positive for oestrogen receptors (meaning the cancer is driven by hormones).
• People whose tumour tests negative for a protein called HER2.
• People whose sentinel node (the first lymph node checked for cancer spread) shows no cancer cells, or only isolated tumour cells.
• People who may also have a small, non-extensive area of DCIS (a non-invasive form of breast change) alongside their main tumour.
• People who may have an indication for hormone-blocking (endocrine) therapy.
• People who can communicate and understand Dutch adequately.

Who may not be able to join:

• People who are not legally able to give their own consent to participate.
• People who carry a BRCA1, BRCA2, or CHEK2 gene mutation.
• People whose cancer has spread to other parts of the body (distant metastasis).
• People who have previously had breast cancer or DCIS.
• People who have had another type of cancer within the 5 years before their breast cancer diagnosis (people whose previous cancer was treated more than 5 years ago may still be considered eligible by the trial site).
• People who have had certain skin or cervical cancers may still be considered — no specific time period applies in those cases (confirm with trial site).
• People who have a collagen synthesis (connective tissue) disease.
• People whose biopsy or imaging shows an extensive DCIS component alongside the main tumour (for example, widespread calcium deposits on mammogram).
• People whose tumour is invasive lobular carcinoma.
• People for whom an MRI scan is not safe or possible (as determined by the radiology department).
• People whose lymph nodes have been confirmed to contain cancer cells through a cell or tissue sample.
• People who have an indication for chemotherapy or HER2-targeted therapy according to Dutch national or hospital guidelines.
• People for whom a suitable radiation therapy treatment plan cannot be created.

Important: Always verify eligibility with the trial site directly before applying.