Pulmonary Hypertension Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• The patient must be a pregnant woman between 18 and 45 years of age
• The pregnancy must be a single baby (not twins or more)
• The baby must be between 28 weeks and 31 weeks and 6 days of pregnancy at the time of assessment
• The baby must have a confirmed severe diagnosis of a condition called congenital diaphragmatic hernia (CDH), where the diaphragm has not developed properly, affecting either the left or right side, with specific measurements showing very small lung volume and a significant portion of the liver pushed into the chest cavity
• The baby's heart scan must be normal, or show only a minor finding that a specialist heart doctor does not expect to affect the baby's health after birth
• The baby's chromosome and genetic testing must come back normal
• The mother must be healthy enough to undergo surgery
• The patient and the baby's father must sign a consent form that explains the risks of the procedure to both mother and baby
• The patient must be willing to stay in Houston from the time of the procedure until the baby is born

Who may not be able to join:

• People for whom abdominal surgery, keyhole surgery on the baby, or general anesthesia is not safe
• People with a latex allergy
• People with a known allergy or previous bad reaction to any medication specified in this study
• People who have preterm labour, a pregnancy-related high blood pressure condition (preeclampsia), or an abnormality of the uterus (such as large fibroid tumours) in this pregnancy
• Cases where the baby has abnormal chromosomes, known significant genetic variants, other major physical abnormalities that may affect the baby's survival, or a known genetic syndrome
• Cases where a major recognised syndrome (such as Fryns syndrome) is suspected based on ultrasound or MRI scans
• People with a body mass index (BMI) over 40
• Cases where there is a high risk that the baby may have haemophilia

Important: Always verify eligibility with the trial site directly before applying.