Phase 2 Breast Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• Your tumor tissue (either stored samples or a fresh biopsy) must test positive for a protein called RSK2
• Your breast cancer must be hormone receptor-positive (HR+) and HER2-negative, confirmed by a tissue or cell sample test
• Your cancer must not have a specific gene change called an ESR1 mutation (meaning the ESR1 gene is in its normal form)
• You must have been diagnosed with breast cancer that has either spread to other parts of the body, or is locally advanced in a way that cannot be treated with surgery or radiation to cure it
• You must be a suitable candidate for hormone-based treatment (endocrine therapy)
• You must have already received at least one hormone-based treatment for advanced or metastatic breast cancer, or your cancer came back while you were on hormone therapy after earlier treatment
• You must have stopped your previous hormone therapy at least 15 days before starting this trial
• You must have at least one area of cancer that can be measured on a scan, following standard measurement guidelines
• Your cancer must have continued to grow during or after treatment with a CDK4/6 inhibitor drug combined with hormone therapy
• Your blood, liver, and kidney function must be within acceptable ranges based on lab tests
• Any side effects from previous treatments must have mostly cleared up before joining (confirm with trial site)

Who may not be able to join:

• You have previously received chemotherapy
• Your tumor has an ESR1 gene mutation
• You have received another experimental or biological therapy within the last 14 days
• Your cancer has spread to internal organs in a way that is causing a serious, urgent health crisis that would normally require chemotherapy
• Your cancer has spread to the brain or spinal cord, unless it has been treated and your condition is neurologically stable
• You have a history of cancer spreading to the membranes surrounding the brain or spinal cord (leptomeningeal metastases)
• You have an active infection (bacterial, viral, or fungal) that requires ongoing treatment
• You have a known hepatitis B or hepatitis C infection
• You are HIV-positive with a low immune cell count (below 350 CD4+ cells) or have had a serious HIV-related infection in the past
• You have a significant history of heart problems, including an abnormal heart rhythm measurement above a certain level on an ECG (confirm with trial site)

Important: Always verify eligibility with the trial site directly before applying.