Ovarian Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People between 35 and 50 years old (inclusive)
• People who are planning to have both ovaries and fallopian tubes surgically removed to reduce cancer risk, OR people who have been fully counselled about that surgery but have chosen to delay or decline it and are instead having only their fallopian tubes removed for now
• People who have at least one ovary and fallopian tube still in place at the time of joining the trial (previous removal of the uterus alone is allowed, as is previous tubal ligation, as long as one ovary and fallopian tube with its fimbria — the fringe-like end — remain)
• People who have a confirmed gene test result, from an approved laboratory, showing a harmful or likely harmful change in the BRCA1 gene, with written documentation of that result
• People who are either still having periods or have gone through menopause
• People who have had a pelvic ultrasound or pelvic MRI scan, and a CA-125 blood test (a marker sometimes associated with ovarian conditions), within the past 180 days before joining
• People who are currently pregnant, or who plan to become pregnant in the future through assisted reproductive technologies, provided they have received proper counselling — including that natural pregnancy will no longer be possible after the surgery
• People who are currently pregnant and plan to have their fallopian tubes removed during a planned caesarean section
• Consent must be given by the patient or their legally authorised representative before entering the study

Who may not be able to join:

• People with a history of any cancer who have received chemotherapy (cell-killing drug treatment) in the past 30 days, or radiotherapy to the abdomen or pelvis at any point in the past (note: certain ongoing maintenance therapies — including hormone therapy, HER2-targeted therapy, immune checkpoint inhibitors, and PARP inhibitor therapy — are permitted; confirm with trial site)
• People with a prior history of ovarian cancer, including borderline ovarian tumours, primary peritoneal cancer, or fallopian tube cancer
• People who are not medically well enough to safely undergo the planned surgery
• People whose recent pelvic ultrasound, pelvic MRI, or CA-125 blood test results are concerning for a possible hidden or visible pelvic cancer — specifically:
  • A pelvic scan showing features suspicious for ovarian cancer (simple cysts of any size, or complex cysts considered likely to be non-cancerous, do not disqualify someone)
  • A CA-125 blood level above 50 U/ml in people who are still having periods and not taking the contraceptive pill; above 40 U/ml in people still having periods who are taking the contraceptive pill; or above 35 U/ml in people who have gone through menopause

Important: Always verify eligibility with the trial site directly before applying.