Phase 3 Breast Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have been confirmed by a tissue test (biopsy) to have invasive breast cancer in one breast only
• People for whom radiation therapy has been recommended
• People for whom chemotherapy before surgery (which may include antibody treatment or other targeted therapies) has been recommended, in line with standard medical guidelines
• People who are female
• People who have signed the official consent form for the trial
• People with any hormone receptor or HER2 status (no restrictions apply to these test results)
• People with any tumour grade (G1, G2, or G3)
• People aged 18 or older at the time of signing the consent form
• People with a general health/activity level rated at 2 or below on a standard medical scale (confirm with trial site)
• People with no existing health conditions that would prevent treatment

Who may not be able to join:

• People whose only planned pre-surgery treatment is hormone therapy (without chemotherapy)
• People who have breast cancer in both breasts
• People who are pregnant or breastfeeding
• People who have previously had radiation therapy to the chest area
• People who have a connective tissue disease, such as rheumatoid arthritis or a condition involving blood vessel inflammation (thromboangiitis obliterans)
• People who have an existing, symptomatic chronic lung condition, such as lung scarring (fibrosis), dust-related lung disease, severe lung conditions caused by allergies (such as farmer's lung), severe emphysema, or advanced COPD
• People with certain heart conditions, including symptomatic coronary heart disease, a previous heart attack, heart failure of a certain severity, or who have a pacemaker or implanted defibrillator (confirm severity levels with trial site)
• People who have or have had another cancer, except for a specific type of skin cancer (basalioma) or non-invasive cancers that have fully cleared
• People whose cancer has spread to distant parts of the body (metastasis)
• People who have nerve problems affecting the arm on the same side as the affected breast
• People who have shoulder stiffness on the same side as the breast cancer, regardless of the cause (for example, following an injury)
• People who have moderate to severe arm swelling (lymphoedema rated grade II or higher) on the same side as the breast cancer
• People with other medical conditions that would prevent them from safely receiving pre-surgery radiation therapy, including an expectation that they would not be able to follow the treatment plan
• People who are male
• People who have already had an assessment of how their cancer responds to chemotherapy

Important: Always verify eligibility with the trial site directly before applying.