Ovarian Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are at least 18 years old
• You are generally healthy and able to carry out most daily activities (confirm with trial site regarding fitness level assessment)
• You have been diagnosed with a specific type of uterine cancer called endometrioid adenocarcinoma, confirmed by a biopsy or a procedure to sample the uterine lining
• Scans and physical examination show the cancer appears to be contained within the uterus, with no signs of spread to other areas, lymph nodes, or the cervix
• You are considered healthy enough to have surgery
• Your planned surgery includes removal of the uterus (hysterectomy), removal of the ovaries and fallopian tubes on both sides, and a procedure to check specific nearby lymph nodes (sentinel lymph node biopsy)
• You have not had another cancer (other than certain common skin cancers) in the past 5 years
• You have not had chemotherapy or radiation therapy for uterine cancer before
• You have not had any previous radiation treatment to your pelvis or abdomen
• You have read and signed a form agreeing to take part in the trial
• After surgery, your final pathology report confirms the cancer is a Stage I intermediate-risk endometrioid cancer and is still confined to the uterus (confirm exact staging details with trial site)
• After surgery, the sentinel lymph nodes that were tested came back negative (no cancer found in those lymph nodes)
• The fluid tested from inside your abdomen during surgery showed no cancer cells
• After surgery, your medical team recommends either no further treatment or radiation treatment directed only to the vaginal area

Who may not be able to join:

• Scans or physical examination suggest the cancer has spread beyond the uterus, to lymph nodes, or to the cervix before surgery
• There is a medical reason why the sentinel lymph node mapping procedure cannot be done
• Your planned treatment does not include surgery, or the surgery does not include removal of the uterus, both ovaries and fallopian tubes, and the sentinel lymph node procedure
• During surgery, cancer is found outside the uterus or in the lymph nodes
• Any cancer cells — even very small amounts — are found in the pelvic lymph nodes after surgery
• The uterus is not removed during surgery
• Both ovaries and fallopian tubes are not removed (unless one side had already been removed before this trial)
• The sentinel lymph node mapping procedure does not work on one or both sides
• A full removal of all pelvic lymph nodes is carried out during surgery
• A more extensive type of hysterectomy (called a radical type C hysterectomy) is performed
• The final pathology report shows the earliest stage and lowest-grade form of this cancer (Stage IA, Grade 1 or 2, with less than half of the uterine wall affected)
• The final pathology report shows a more advanced form (Stage IB, Grade 3)
• The final pathology report shows a different type of uterine cancer (such as serous, clear cell, or other specific types) rather than endometrioid
• The lymph node samples collected during surgery come back empty (no lymph node tissue found to test)
• Cancer cells are found in the abdominal fluid tested during surgery

Important: Always verify eligibility with the trial site directly before applying.