Phase 3 Oesophageal Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People whose cancer has been confirmed by tissue testing to be a specific type of esophageal cancer: squamous cell carcinoma, adenosquamous carcinoma, or basaloid cell carcinoma.
• People whose main cancer lesion is located in the chest portion of the food pipe (esophagus), though some secondary lesions may be in other areas (confirm with trial site).
• People whose scans (CT with contrast dye) show the cancer has not spread to nearby lymph nodes or other parts of the body.
• People whose cancer is assessed by internal camera examination (endoscopy) as having grown into a specific depth of the esophagus wall, known as the submucosal layer (cT1b).
• People aged 20 years or older.
• People who are generally well enough to carry out daily activities, with minimal or no limitations (ECOG performance score of 0 or 1).
• People who have not had any prior treatment for esophageal cancer, except for a complete removal of an earlier lesion by endoscopic procedure (EMR/ESD) that met specific pathology criteria (confirm with trial site).
• People who have not had radiotherapy to the neck, chest, or upper abdomen for any cancer, and have not had chemotherapy or hormone therapy within the past 3 years for any cancer.
• People whose major organ functions (blood counts, liver, kidney, and oxygen levels) meet the required blood test thresholds (confirm with trial site for specific values).
• People who, after receiving a full explanation, do not have a strong preference to have surgery as their first treatment.
• People who are willing and able to provide written consent to participate.

Who may not be able to join:

• People who have had another cancer at the same time or within the past 5 years, unless it was a very early surface-level cancer treatable with local therapy.
• People who currently have an active infection that requires treatment with systemic (whole-body) medications.
• People who have a fever above 38 degrees Celsius.
• People who are pregnant, have given birth within the past 28 days, or are currently breastfeeding; also, males whose partner is trying to become pregnant.
• People who have a psychological condition that would make it difficult to participate in the study (confirm with trial site).
• People who are currently taking ongoing systemic steroid or immune-suppressing medications.
• People who test positive for Hepatitis B surface antigen or HIV antigen.
• People with diabetes that cannot be adequately controlled despite ongoing use of insulin or blood sugar-lowering medications.
• People with high blood pressure that is not adequately controlled.
• People who have had unstable chest pain (angina) within the past 3 weeks, or a heart attack within the past 6 months.
• People with serious uncontrolled heart valve disease, a type of enlarged heart (dilated cardiomyopathy), or a thickened heart muscle condition (hypertrophic cardiomyopathy).
• People whose chest CT scan shows severe emphysema, interstitial pneumonia, or lung scarring (pulmonary fibrosis).
• People who have had a stroke or related brain blood vessel event within the past 6 months.
• People who have a known allergy to iodine-based substances (such as contrast dye used in CT scans).

Important: Always verify eligibility with the trial site directly before applying.