Phase 4 Asthma Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• Adults between 18 and 40 years old
• People who have been diagnosed with asthma by a doctor for at least 6 months
• People whose asthma has been well controlled (scoring 20 or above on the Asthma Control Test) for the 6 months before joining the trial
• People whose lung function test shows their lungs are working at more than 80% of the expected level for someone their age and size
• People whose asthma is managed with a reliever inhaler (albuterol) alone, or with a reliever inhaler plus a low-to-medium dose steroid inhaler, with or without other controller medicines — and who are not using any anti-inflammatory medicines for nose or sinus conditions
• People who test positive on a methacholine challenge test, which checks how sensitive the airways are (confirm with trial site)
• People who have a raised level of certain immune cells (eosinophils) in their blood, or a raised level of a marker of airway inflammation measured in their breath (FeNO) (confirm with trial site)
• People who test negative for certain antibodies to two specific cold viruses (HRV 16 and HRV 39) (confirm with trial site)
• People who are willing and able to attend clinic visits and follow study procedures
• People who are able to give their own signed consent to take part
• People who are able to understand and fill in study questionnaires

Who may not be able to join:

• People who currently smoke, or who have smoked regularly for 10 or more years with a heavy smoking history (more than 10 pack-years)
• People with a history or signs of COPD or any other significant lung disease
• People with a known allergy to any ingredient in the study treatment
• People who have received a biologic therapy for asthma (including dupilumab) in the last 3 months
• People who have used antiviral, immune-suppressing, or immune-modifying treatments in the last 3 months
• People who use any inhaled nasal sprays
• People who have had an upper or lower respiratory tract infection in the last 6 weeks
• People who have had an asthma flare-up in the last 6 weeks
• People who have ever had a serious asthma attack that required a visit to an emergency department, being placed on a breathing machine, or a hospital stay
• People who have had an asthma flare-up in the past 3 years that required an unplanned doctor's visit or a course of steroid tablets
• Members of the clinical trial team at the study site, or their immediate family members
• People who are pregnant or breastfeeding
• Women who could become pregnant and are unwilling to use highly effective contraception before, during, and for at least 4 months after the study treatment. Accepted methods include hormonal contraception (pill, patch, ring, injection, or implant) started at least two menstrual cycles before the study, an intrauterine device (IUD or IUS), surgical sterilisation (tubal ligation), a partner who has had a vasectomy, or complete abstinence from heterosexual intercourse throughout the study period. Note: certain methods such as condoms alone, spermicides, the rhythm method, and withdrawal are not considered acceptable (confirm details with trial site)

Important: Always verify eligibility with the trial site directly before applying.