Phase 3 Alzheimer's Disease Trial, Recruiting NCT04390646 Sponsor: Nelly Pitteloud Condition: Alzheimer's Disease
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Phase 3 Alzheimer's Disease Trial, Recruiting

NCT04390646
Recruiting Phase 3

Who may be able to join

AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI

Who might be able to join this trial:

  • You have been diagnosed with trisomy 21 (Down syndrome)
  • You are able to speak and communicate well enough to take part in the study procedures
  • You agree to use non-hormonal contraception for the whole time you are in the study (for women: a copper coil/IUD, having had a tubal ligation, or your partner using condoms; for men: using condoms or having had a vasectomy)

Who may not be able to join:

  • You are currently unwell with an acute illness or have recently been hospitalised
  • You regularly drink large amounts of alcohol, use illegal drugs, take anabolic steroids, or use psychotropic (mind-affecting) drugs, as reported by your caregivers
  • You are currently taking certain medications that affect hormones, including spironolactone, ketoconazole, blood thinners (anticoagulants), steroids, ACTH hormone, or any mental health medications such as antidepressants, antipsychotics, or anti-seizure drugs
  • You have a known tumour on the pituitary gland or any other tumour that is affected by hormones
  • You are already taking part in another clinical trial
  • You are planning to have a child during the time the study is running
  • For women: you have ovarian cysts, a condition causing irregular periods that is not related to the brain (such as polycystic ovary syndrome), or you are currently pregnant or breastfeeding
  • For men: your red blood cell level (hematocrit) is above 54% (confirm with trial site)
  • You have a reason you cannot have an MRI scan, such as having a pacemaker or metal clips in your body
  • You or your legal representative do not wish to be told if something unexpected is found during the study

Important: Always verify eligibility with the trial site directly before applying.

Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.

This is a simplified plain English summary of the eligibility criteria. Full criteria are set by the trial investigators and may include additional requirements not shown here. Never self-exclude from a trial based on this summary. Contact the trial site directly to confirm your eligibility.
Last synced 9 July 2026
Phase 3: approximately ~65% of drugs entering this phase reach regulatory approval, based on published industry-wide historical data. This is not specific to this trial.
Phase success rates shown are historical industry-wide averages based on published data. They are not a prediction for this specific trial or your individual situation.

Contact this trial

Principal Investigator: Nelly Pitteloud, MD, Endocrinology, Metabolism, Diabetology (CHUV)

Phone: +41 21 314 06 25

Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.

GP referral letter

Print a one-page summary to share with your doctor.

Trial details

Status
Recruiting
Phase
Phase 3
Sponsor
Nelly Pitteloud
Registry
ClinicalTrials.gov
Start date
27 August 2020
Est. completion
1 December 2028

Where this trial is recruiting

🇨🇭 Switzerland

Primary endpoints

Cognition

Can't join this trial?

Expanded access pathways

If this trial is not available to you, other access pathways may exist. In Australia, the TGA Special Access Scheme allows access to unapproved therapeutic goods for individual patients.

TGA Special Access Scheme information

Find other recruiting trials on ClinicalTrials.gov

Data last synced from ClinicalTrials.gov: 9 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.

Trial recruitment status can change without notice between our nightly data updates. Always contact the trial site directly to confirm current recruitment status before making any decisions or travel arrangements.

View original record on ClinicalTrials.gov