Phase 2 Osteoarthritis Trial, Recruiting NCT04427709 Sponsor: Wake Forest University Health Sciences Condition: Osteoarthritis
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Phase 2 Osteoarthritis Trial, Recruiting

NCT04427709
Recruiting Phase 2

Who may be able to join

AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI

Who might be able to join this trial:

  • You are between 19 and 74 years old, and your body weight falls within a healthy to moderately overweight range (BMI under 40)
  • You are generally in good health, as assessed by the lead doctor based on your medical history
  • If you are a healthy volunteer, your blood pressure and resting heart rate are in a normal range without needing medication; if you have knee arthritis and high blood pressure, it must be well-controlled with medication, and your resting heart rate must be in a normal range
  • If you are a woman who could become pregnant or who has gone through menopause less than a year ago, you must be using a reliable form of birth control (such as hormonal contraceptives, double barrier methods, or complete abstinence) for at least one full monthly cycle before taking the study drug

Who may not be able to join:

  • You have had an allergic reaction or sensitivity to any ingredient in Pitocin® (a form of oxytocin)
  • You have a medical or surgical condition that the lead doctor believes could put you at risk, affect your ability to follow the study procedures, or affect the quality of results (for example, certain uterine conditions with active bleeding)
  • You are currently pregnant, breastfeeding, or have been pregnant within the last 2 years
  • You have nerve damage (neuropathy), chronic pain, diabetes, or you take benzodiazepines or pain medications every day
  • You have eye problems, have had eye surgery, use eye drops regularly, or have any condition that causes shaking or unusual eye movements

Important: Always verify eligibility with the trial site directly before applying.

Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.

This is a simplified plain English summary of the eligibility criteria. Full criteria are set by the trial investigators and may include additional requirements not shown here. Never self-exclude from a trial based on this summary. Contact the trial site directly to confirm your eligibility.
Last synced 5 July 2026
Phase 2: approximately ~30% of drugs entering this phase reach regulatory approval, based on published industry-wide historical data. This is not specific to this trial.
Phase success rates shown are historical industry-wide averages based on published data. They are not a prediction for this specific trial or your individual situation.

Contact this trial

Principal Investigator: James C Eisenach, MD, Wake Forest University Health Sciences

Phone: 336-716-4294

Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.

GP referral letter

Print a one-page summary to share with your doctor.

Trial details

Status
Recruiting
Phase
Phase 2
Registry
ClinicalTrials.gov
Start date
30 November 2020
Est. completion
1 December 2026

Where this trial is recruiting

🇺🇸 United States

Primary endpoints

Fluctuation in Pupil Diameter (Hippus) -Pre drug administration; Fluctuation in Pupil Diameter (Hippus) -Post drug administration

Can't join this trial?

Expanded access pathways

If this trial is not available to you, other access pathways may exist. In Australia, the TGA Special Access Scheme allows access to unapproved therapeutic goods for individual patients.

TGA Special Access Scheme information

Find other recruiting trials on ClinicalTrials.gov

Data last synced from ClinicalTrials.gov: 5 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.

Trial recruitment status can change without notice between our nightly data updates. Always contact the trial site directly to confirm current recruitment status before making any decisions or travel arrangements.

View original record on ClinicalTrials.gov