Early Phase 1 Osteoarthritis Trial, Recruiting (NCT04572256)

Early Phase 1 Osteoarthritis Trial, Recruiting NCT04572256 Sponsor: Austin V Stone Condition: Osteoarthritis

Printed from Voxsanity (voxsanity.com.au) — NCT04572256 — Data sourced from ClinicalTrials.gov. Verify directly with the trial site before attending. Not medical advice.

Back to Osteoarthritis

Who may be able to join

AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI

Who might be able to join this trial:

People who are having their ACL (a knee ligament) reconstructed for the first time
People between the ages of 25 and 50
People who also have an injury to the meniscus (the cartilage cushion in the knee)

Who may not be able to join:

People who are having a repeat or revision surgery on a previously repaired ACL
People who have injuries to more than one knee ligament, all of which need surgical repair or reconstruction
People who are experiencing significant symptoms of depression or thoughts of suicide at the time of joining the trial, as measured by a standard questionnaire (PHQ-9 score of 15 or higher)
People for whom no meniscus tear is found during surgery

Important: Always verify eligibility with the trial site directly before applying.

Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.

This is a simplified plain English summary of the eligibility criteria. Full criteria are set by the trial investigators and may include additional requirements not shown here. Never self-exclude from a trial based on this summary. Contact the trial site directly to confirm your eligibility.

Last synced 20 July 2026

Early Phase 1 studies are small, early exploratory studies that come before the main Phase 1 to 3 testing, so a standard phase success rate does not apply.

Contact this trial

Principal Investigator: Austin Stone, MD, PhD, University of Kentucky

Phone: 859.218.3065

Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.

GP referral letter

Print a one-page summary to share with your doctor.

Voxsanity

Clinical trials and treatments, explained plainly · voxsanity.com.au

Date:

To: My Doctor

Re: Clinical trial enquiry

I am writing to enquire about the following clinical trial which may be relevant to my care:

Trial: NCT04572256

Sponsor: Austin V Stone

Phase: Early Phase 1

Status: Recruiting

Condition: Osteoarthritis

Trial contact: 859.218.3065

More information: https://clinicaltrials.gov/study/NCT04572256

Eligibility summary (AI generated)

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

People who are having their ACL (a knee ligament) reconstructed for the first time
People between the ages of 25 and 50
People who also have an injury to the meniscus (the cartilage cushion in the knee)

Who may not be able to join:

People who are having a repeat or revision surgery on a previously repaired ACL
People who have injuries to more than one knee ligament, all of which need surgical repair or reconstruction
People who are experiencing significant symptoms of depression or thoughts of suicide at the time of joining the trial, as measured by a standard questionnaire (PHQ-9 score of 15 or higher)
People for whom no meniscus tear is found during surgery

Important: Always verify eligibility with the trial site directly before applying.

Access in Australia: A treatment being studied in a clinical trial is generally not yet listed on the PBS. Where a medicine is not approved or not available through a trial, the TGA Special Access Scheme may allow a doctor to access unapproved therapeutic goods for individual patients. See voxsanity.com.au/sas-navigator/ for a plain English explainer.

This information was sourced from ClinicalTrials.gov via Voxsanity (data last synced 20 July 2026). It is not medical advice. Please verify the trial's current status directly with the trial site before acting.

Trial details

Status

Recruiting

Phase

Early Phase 1

Sponsor

Austin V Stone

Registry

ClinicalTrials.gov

Start date

1 February 2021

Est. completion

1 June 2027

Where this trial is recruiting

🇺🇸 United States

Primary endpoints

Serum prostaglandin E2; T1rho relaxation time on MRI; Shape of the medial femoral condyle on MRI; Knee injury and Osteoarthritis Outcome Score (KOOS)

Can't join this trial?

Expanded access pathways

If this trial is not available to you, other access pathways may exist. In Australia, the TGA Special Access Scheme allows access to unapproved therapeutic goods for individual patients.

TGA Special Access Scheme information

Find other recruiting trials on ClinicalTrials.gov

Data last synced from ClinicalTrials.gov: 20 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.

Trial recruitment status can change without notice between our nightly data updates. Always contact the trial site directly to confirm current recruitment status before making any decisions or travel arrangements.

View original record on ClinicalTrials.gov