Phase 1 Oesophageal Cancer Trial, Recruiting

Written by an AI model from ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• People who have been diagnosed with a confirmed type of cancer called adenocarcinoma, located in the esophagus (food pipe) or at the junction where the esophagus meets the stomach
• People whose esophageal cancer is classified as stage II or stage III
• People who are medically fit enough to receive a combined treatment of chemotherapy and radiation therapy, using one of the following chemotherapy combinations: oxaliplatin with 5-FU or capecitabine; docetaxel and/or 5-FU or paclitaxel; or carboplatin with paclitaxel
• People whose tumor can be reached for a special injection procedure using an ultrasound-guided scope (called an endoscopic ultrasound), as judged by the treating doctor — including some cases where the scope cannot pass all the way through the tumor
• People who have between 1 and 4 measurable tumors in the esophagus that can be tracked over time using standard imaging scans, with nearby lymph node involvement also allowed under certain size conditions
• People with a general health and activity level rated as 0, 1, or 2 on a standard medical scale (meaning able to carry out at least some daily activities)
• People whose blood test results meet minimum levels for red blood cells, white blood cells, and platelets (confirm specific thresholds with trial site)
• People whose kidney function meets the minimum levels required, as measured by blood and urine tests (confirm specific thresholds with trial site)
• People whose liver function falls within acceptable ranges, as measured by blood tests (confirm specific thresholds with trial site)
• Women of childbearing potential who have a negative pregnancy test within 7 days before the injection procedure
• People who have read and signed a consent form confirming they understand the study and are willing to take part

Who may not be able to join:

• People who have previously received radiation therapy or any other treatment for esophageal cancer
• People who have previously had surgery to remove an esophageal tumor
• People whose esophageal cancer has spread to other parts of the body (metastases), as seen on scans at the time of screening
• People with a past medical history of a hole or abnormal connection involving the esophagus (esophageal fistula or tracheoesophageal fistula), or a specific tumor type called Siewert type III
• People whose tumor is large or positioned in a way that the treating doctor believes could cause a dangerous connection to form between the esophagus and airway (confirm with trial site)
• People who have had an active or poorly controlled stomach or esophageal ulcer within 28 days before enrolling
• People who have a known allergy or medical reason preventing the use of certain contrast dyes used in imaging scans (iodine-based or gadolinium-based)
• People who have another active cancer, other than esophageal cancer — with exceptions for certain treated skin cancers or low-risk prostate cancer that has been successfully treated and has not returned for at least 3 months
• People with serious uncontrolled health conditions such as active infection, heart failure, unstable chest pain, kidney failure, irregular heartbeat, or a mental health condition that could affect their ability to follow the study plan
• People with active, uncontrolled HIV, hepatitis B, or hepatitis C infection
• Women who are pregnant or currently breastfeeding
• Women of childbearing potential, and their male partners, who are unwilling or unable to use a highly effective method of contraception throughout the entire study period
• People for whom the study doctor believes participation would not be in their best interest, or where a condition might interfere with the study assessments

Important: Always verify eligibility with the trial site directly before applying.