Phase 2 Lymphoma Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You have been diagnosed with a type of brain or spinal cord lymphoma (primary central nervous system lymphoma) confirmed by a tissue test, and after completing standard chemotherapy, your cancer has fully or partially responded to treatment.
• You are not able to have a stem cell transplant, either because you are 65 or older, your overall health is considered too weak for high-dose chemotherapy, or you have chosen not to have a stem cell transplant.
• Your blood test results meet certain minimum levels for white blood cells, platelets, red blood cells, calcium, kidney function, and liver function (confirm with trial site for exact values).
• If you have hepatitis B, you are already receiving and responding to antiviral treatment for it.
• You are able to carry out basic daily activities with little to no limitation (confirm with trial site).
• You are able to swallow and take oral (by mouth) medication.
• You agree to take part and sign a consent form as required.
• If you are a woman who could become pregnant, you must have two negative pregnancy tests before starting the study medication, taken at specific times before your first dose.
• You must use an effective method of birth control during the trial and for 28 days after your last dose, whether you are male or female and sexually active with someone who could become pregnant.

Who may not be able to join:

• You are planning to have a stem cell transplant after chemotherapy.
• You have serious, poorly controlled heart problems, such as severe heart failure, ongoing chest pain from heart disease, or a heart attack within the last six months.
• You currently have an active serious infection that requires antibiotics, antiviral drugs (other than those treating hepatitis B), or antifungal medication.
• You have uncontrolled hepatitis C or hepatitis B (unless you are already on antiviral treatment for hepatitis B and it is working).
• You are HIV positive.
• You are unable to take medication by mouth.
• You have had another type of cancer in the past, unless you have been cancer-free for at least 5 years, or you had certain skin cancers or early cervical cancer that were fully treated at least 1 year ago.
• You have had severe gastrointestinal (digestive tract) bleeding within the 30 days before joining the trial.
• You have had a blood clot or blockage in a blood vessel within the 6 months before joining the trial.
• You have had a serious allergic reaction to the study drug or any of its ingredients (confirm with trial site).
• You have a seizure (epilepsy) condition that requires medication to control it.
• You are pregnant or currently breastfeeding.
• You have a rare inherited condition affecting how your body processes certain sugars, such as galactose intolerance or a related condition (confirm with trial site).
• You have had a serious allergic reaction to a medication called rituximab.

Important: Always verify eligibility with the trial site directly before applying.