Phase 3 Lymphoma Trial, Recruiting NCT04638790 Sponsor: State Budgetary Healthcare Institution, National Medical Surgical Center N.A. N.I. Pirogov, Ministry of Health of Russia Condition: Lymphoma
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Phase 3 Lymphoma Trial, Recruiting

NCT04638790
Recruiting Phase 3

Who may be able to join

AI generated eligibility summary. Written by an AI model from the official source data and checked on a sample basis. It can contain mistakes, so confirm anything important against the original source. How we use AI

Who might be able to join this trial:

  • People who have been diagnosed with classical Hodgkin Lymphoma (a type of blood cancer), confirmed by a tissue sample test
  • People who have not yet received any treatment for this condition
  • People between the ages of 18 and 55 years old (confirm with trial site, as the upper age limit appears unclear in the source document)
  • People who are generally well enough to carry out daily activities, based on a standard health scale (ECOG score of 2 or lower)
  • People whose blood counts meet minimum levels — specifically, a certain type of infection-fighting white blood cell count above 1.0 x10⁹/L, and platelet count above 75 x10⁹/L
  • People whose liver function results fall within acceptable levels, based on a substance called bilirubin being below a certain threshold
  • People whose kidneys are functioning adequately, based on standard blood or urine tests
  • Women who could potentially become pregnant must have a negative pregnancy test result taken under medical supervision, even if they have been using contraception
  • People with a life expectancy of more than 6 months
  • People who are able to attend all required study visits and follow the study's requirements
  • People (or their legal representative) who are willing to sign a consent form showing they understand and agree to take part in the study
  • People who have access to a PET-CT scanning facility (a specialised imaging scan used to monitor the condition)

Who may not be able to join:

  • People whose Hodgkin Lymphoma is of a specific type called Nodular Lymphocyte Predominant Hodgkin Lymphoma
  • People who have previously received chemotherapy or radiation therapy
  • People who are pregnant or currently breastfeeding
  • People with certain heart conditions, including irregular heartbeat, problems with the heart's electrical signals, reduced heart pumping function, or a specific heart measurement (left ventricular ejection fraction) of 50% or below on a heart ultrasound
  • People with an abnormal result on a specific heart electrical test (QTc interval), above certain thresholds depending on sex
  • People with an infection that is not currently under control
  • People who are HIV positive, or who have active Hepatitis A, B, or C infection. People who test negative for active Hepatitis B but show signs of past exposure may still be considered, provided further specific blood tests are negative and they receive appropriate antiviral medication (confirm with trial site)
  • People with diabetes that is not well managed
  • People who are unwilling to use adequate contraception during the trial
  • People with any medical or mental health condition that, in the treating doctor's judgement, could interfere with completing the treatment

Important: Always verify eligibility with the trial site directly before applying.

Based on publicly available eligibility criteria from ClinicalTrials.gov. Verify directly with the trial site before acting. This is not medical advice.

This is a simplified plain English summary of the eligibility criteria. Full criteria are set by the trial investigators and may include additional requirements not shown here. Never self-exclude from a trial based on this summary. Contact the trial site directly to confirm your eligibility.
Last synced 9 July 2026
Phase 3: approximately ~65% of drugs entering this phase reach regulatory approval, based on published industry-wide historical data. This is not specific to this trial.
Phase success rates shown are historical industry-wide averages based on published data. They are not a prediction for this specific trial or your individual situation.

Contact this trial

Principal Investigator: Vladislav Sarzhevskiy, PhD, State Budgetary Healthcare Institution, National Medical Surgical Center N.A. N.I. Pirogov, Ministry of Health of Russia

Phone: +7-910-436-00-40

Contact details sourced from ClinicalTrials.gov. Verify directly with the trial site before attending.

GP referral letter

Print a one-page summary to share with your doctor.

Trial details

Status
Recruiting
Phase
Phase 3
Sponsor
State Budgetary Healthcare Institution, National Medical Surgical Center N.A. N.I. Pirogov, Ministry of Health of Russia
Registry
ClinicalTrials.gov
Start date
1 February 2020
Est. completion
31 December 2026

Where this trial is recruiting

🇮🇳 India 🇷🇺 Russia

Primary endpoints

Complete remission rate (CR); Acute Toxicity; Late Toxicity; Event-Free Survival (EFS); Disease free survival (DFS)

Can't join this trial?

Expanded access pathways

If this trial is not available to you, other access pathways may exist. In Australia, the TGA Special Access Scheme allows access to unapproved therapeutic goods for individual patients.

TGA Special Access Scheme information

Find other recruiting trials on ClinicalTrials.gov

Data last synced from ClinicalTrials.gov: 9 July 2026. Trial status can change. Always verify current status directly with the trial site before making any decision.

Trial recruitment status can change without notice between our nightly data updates. Always contact the trial site directly to confirm current recruitment status before making any decisions or travel arrangements.

View original record on ClinicalTrials.gov