Phase 3 Macular Degeneration Trial, Recruiting

Written by an AI model from the ClinicalTrials.gov eligibility criteria and checked on a sample basis. Please confirm against the original criteria.

Who might be able to join this trial:

• You are aged 50 years or older
• You have bleeding under the retina in one eye (called a submacular haemorrhage) that is related to a wet/exudative form of age-related macular degeneration (AMD), whether or not you have had previous treatment for it
• The bleed in your eye is located at the central part of your vision (the fovea) and is at least a certain minimum size
• The bleed is thick enough when measured by a special eye scan (confirm with trial site for exact measurement)
• Your vision in the affected eye is within a specific range — not better than a certain level, but not worse than being able to count fingers held in front of you

Who may not be able to join:

• You have a serious allergy to fluorescein dye or a dye called ICG, which are used in eye examinations
• You are allergic or sensitive to any of the medicines used in this trial, including alteplase, gentamicin, arginine, phosphoric acid, polysorbate 80, or aflibercept
• You have had a stroke, mini-stroke, or heart attack in the past 6 months
• You are currently taking part in another clinical trial, or have done so within the past 12 weeks
• You are pregnant, breastfeeding, or planning to become pregnant during the trial; women who could become pregnant must agree to use highly effective contraception during the trial and for up to 12 weeks after their last treatment; men must agree to use a condom if their partner could become pregnant, even after a vasectomy
• Your blood-thinning medication level (INR, for those on warfarin) is too high and cannot be safely lowered before surgery (confirm with trial site)
• You are unwilling or unlikely to attend all the required follow-up appointments for the full duration of the trial
• You have a condition such as dementia, mental illness, or serious medical illness that would prevent you from giving consent or following the trial plan, in the opinion of the trial doctor
• The bleed in your eye is known or believed to have been there for more than 15 days
• The bleed in your eye is caused by something other than wet AMD
• You currently have active advanced diabetic eye disease (proliferative diabetic retinopathy)
• You currently have inflammation inside your eye
• You currently have an infection in or around your eye (other than a mild eyelid condition called blepharitis)
• You have, or have previously had, a high level of short-sightedness (more than 6 dioptres)
• You have no natural or artificial lens in the affected eye (a condition called aphakia)
• You have another existing eye condition that, in the opinion of the trial doctor, would prevent your vision from improving even if the bleed resolved — for example, severe scarring at the centre of the retina, a macular hole, or very poor vision that existed before the bleed
• Your pupil cannot be dilated enough, or there are other eye issues, that would prevent a proper examination of the back of your eye
• You have had eye surgery in the affected eye within the past 12 weeks (though uncomplicated cataract surgery within the past 8 weeks may be acceptable — confirm with trial site)

Important: Always verify eligibility with the trial site directly before applying.